Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Previous steroid use and lower baseline HbA1c level may be important predictors for developing diabetes in patients with advanced solid tumors treated with PI3K inhibitors, warranting close observation and careful intervention.
|
31250153 |
2019 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Elabela protects against podocyte injury in mice with streptozocin-induced diabetes by associating with the PI3K/Akt/mTOR pathway.
|
30959144 |
2019 |
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Administering demethylasterriquinone B1, significantly increased the level of PI3K, AKT phosphorylation and GLUT-2 expression, effectively inhibiting the aggravation of diabetes.
|
29526571 |
2018 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we used Petri nets (PNs) to model and investigate the role of PI3K and OGT pathways, acting as key players in crosstalk between diabetes and breast cancer, resulting in progression of these chronic diseases.
|
30515357 |
2018 |
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mice Carrying a Dominant-Negative Human PI3K Mutation Are Protected From Obesity and Hepatic Steatosis but Not Diabetes.
|
29724723 |
2018 |
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
SOCS1-targeted therapy ameliorates renal and vascular oxidative stress in diabetes via STAT1 and PI3K inhibition.
|
29540859 |
2018 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
We speculate that opisthorchiasis and diabetes together aggravate hepatobiliary pathogenesis through an IRS/PI3K/AKT-independent pathway.
|
29953446 |
2018 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our study suggests that HD prevents the development of diabetes and improves renal function in the <i>db/db</i> mice and HD regulation of the IRS1-PI3K-GLUT signaling pathway significantly improves diabetic nephropathy.
|
30210687 |
2018 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
To address this issue, we investigated the effects of PI3Kγ ablation in <i>db/db</i> diabetic mice, a genetic model of obesity-driven β-cell failure and diabetes.
|
28904022 |
2018 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
The protein and lipid kinase phosphoinositide 3-kinases (PI3Ks) have been suggested to regulate cardiac injury during diabetes.
|
28654509 |
2017 |
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Genetic variations in the PI3K/AKT/mTOR signaling pathway may be associated with an increasing risk of obesity and diabetes.
|
28477532 |
2017 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
These studies demonstrate that EPO is an effective neuroprotective agent in the context of diabetes-associated cognitive dysfunction and show that this effect involves the PI3K/Akt/GSK-3β pathway.
|
28584284 |
2017 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Given the availability of a pharmacological inhibitor of this molecular target GE21, we tested the validity of our hypothesis by inducing diabetes in mice with genetic ablation of PI3Kγ or knock-in for a catalytically inactive PI3Kγ.
|
27422446 |
2017 |
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
An important attribute in diabetes and obesity is the presence of high levels of growth factors including insulin in blood which can activate the PI3K/Akt signalling pathway.
|
28842968 |
2017 |
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Insulin-mediated translocation of GLUT4 involves the PI3K/Akt kinase signal cascade that results in activation of endothelial NO synthase (eNOS). eNOS is dysfunctional during diabetes.
|
24157451 |
2014 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, it's still not clear whether mTOR, another main gene in PI3K/Akt pathway, is also involved in the renal lipogenesis of diabetes.
|
23827786 |
2013 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
The phosphatidylinositol 3 kinase/protein kinase B (PI3K/Akt) pathway mediates the high-glucose-induced lipid accumulation in the renal tubular cells in diabetes.
|
23880101 |
2013 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
N-Acetylcysteine and allopurinol up-regulated the Jak/STAT3 and PI3K/Akt pathways via adiponectin and attenuated myocardial postischemic injury in diabetes.
|
23747931 |
2013 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Accumulating evidences suggest that there are important cross-talks between Nrf2 and PPARγ, PGC1α, PI3K/Akt on regulating antioxidant enzymes and the development of diabetes.
|
21861804 |
2011 |
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Common polymorphisms in the insulin, PC-1 and PI3K genes did not regulate weight change or conversion to diabetes.
|
15127203 |
2004 |