Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Further, to study the H<sub>2</sub>S mode of action, the experimental rats were exposed to a PI3K inhibitor (Wortmannin) and GSK3β inhibitor (SB216763) before HIPC protocol, whose results suggest that unlike in normal and DM, HIPC mediates its cardioprotective effect independent of PI3K/GSK3β pathway.
|
31317389 |
2020 |
Diabetes Mellitus
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Previous steroid use and lower baseline HbA1c level may be important predictors for developing diabetes in patients with advanced solid tumors treated with PI3K inhibitors, warranting close observation and careful intervention.
|
31250153 |
2019 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Firstly, mouse model of diabetes mellitus (DM) was established and injected with agomir, antagomir or IGF-1 (PI3K/Akt signaling pathway activator) for investigating the role of miR-203 in PIK3CA and the PI3K/Akt signaling pathway.
|
31336140 |
2019 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Elabela protects against podocyte injury in mice with streptozocin-induced diabetes by associating with the PI3K/Akt/mTOR pathway.
|
30959144 |
2019 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
LiCl, as an inhibitor of GSK-3 apparently reduced the expression of GSK-3β mRNA (<i>P</i> < 0.05) but not the PI3K and Akt comparing with the DM group.
|
30237226 |
2019 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
In vivo levels of TUG1 and relative genes in the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) pathway in DM rats and control rats were determined by the quantitative Real Time-Polymerase Chain Reaction (qRT-PCR).
|
31539141 |
2019 |
Diabetes Mellitus
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Mice Carrying a Dominant-Negative Human PI3K Mutation Are Protected From Obesity and Hepatic Steatosis but Not Diabetes.
|
29724723 |
2018 |
Diabetes Mellitus
|
0.100 |
AlteredExpression
|
group |
BEFREE |
SOCS1-targeted therapy ameliorates renal and vascular oxidative stress in diabetes via STAT1 and PI3K inhibition.
|
29540859 |
2018 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
In this study, we used Petri nets (PNs) to model and investigate the role of PI3K and OGT pathways, acting as key players in crosstalk between diabetes and breast cancer, resulting in progression of these chronic diseases.
|
30515357 |
2018 |
Diabetes Mellitus
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Administering demethylasterriquinone B1, significantly increased the level of PI3K, AKT phosphorylation and GLUT-2 expression, effectively inhibiting the aggravation of diabetes.
|
29526571 |
2018 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
We aimed to evaluate the expression of hormone and insulin-related proteins within or related to the PI3K and MAPK pathway in breast tumors of women with or without diabetes mellitus, treated with or without insulin (analogues).
|
29486734 |
2018 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Our study suggests that HD prevents the development of diabetes and improves renal function in the <i>db/db</i> mice and HD regulation of the IRS1-PI3K-GLUT signaling pathway significantly improves diabetic nephropathy.
|
30210687 |
2018 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
To address this issue, we investigated the effects of PI3Kγ ablation in <i>db/db</i> diabetic mice, a genetic model of obesity-driven β-cell failure and diabetes.
|
28904022 |
2018 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
HMGA1 Mediated High-Glucose-Induced Vascular Smooth Muscle Cell Proliferation in Diabetes Mellitus: Association Between PI3K/Akt Signaling and HMGA1 Expression.
|
29634420 |
2018 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
We speculate that opisthorchiasis and diabetes together aggravate hepatobiliary pathogenesis through an IRS/PI3K/AKT-independent pathway.
|
29953446 |
2018 |
Diabetes Mellitus
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Here, using <i>in vitro</i> and <i>in vivo</i> approaches including osteoblast-specific, conditional FoxO1-knock-out mice, we demonstrate that 1,25(OH)<sub>2</sub>D<sub>3</sub> ameliorates abnormal osteoblast proliferation in DM-induced oxidative stress conditions and rescues the impaired glucose and bone metabolism through FoxO1 nuclear exclusion resulting from the activation of PI3K/Akt signaling.
|
29042442 |
2017 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
The protein and lipid kinase phosphoinositide 3-kinases (PI3Ks) have been suggested to regulate cardiac injury during diabetes.
|
28654509 |
2017 |
Diabetes Mellitus
|
0.100 |
AlteredExpression
|
group |
BEFREE |
An important attribute in diabetes and obesity is the presence of high levels of growth factors including insulin in blood which can activate the PI3K/Akt signalling pathway.
|
28842968 |
2017 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Given the availability of a pharmacological inhibitor of this molecular target GE21, we tested the validity of our hypothesis by inducing diabetes in mice with genetic ablation of PI3Kγ or knock-in for a catalytically inactive PI3Kγ.
|
27422446 |
2017 |
Diabetes Mellitus
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Genetic variations in the PI3K/AKT/mTOR signaling pathway may be associated with an increasing risk of obesity and diabetes.
|
28477532 |
2017 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
These studies demonstrate that EPO is an effective neuroprotective agent in the context of diabetes-associated cognitive dysfunction and show that this effect involves the PI3K/Akt/GSK-3β pathway.
|
28584284 |
2017 |
Diabetes Mellitus
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In addition, the protein expression levels of phosphatidylinositol 3‑kinase (PI3K)/Akt, glutathione peroxidase and superoxide dismutase activity, glutathione and malondialdehyde content, and inducible nitric oxide synthase (iNOS), caspase‑3 and caspase‑9 activity were detected in the rats with DM.
|
26648531 |
2016 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Moreover, exogenously added TGF-β3 accelerated epithelial wound closure in type 2 rat and type 1 mouse DM corneas via Smad and PI3K-AKT signaling pathways, autoregulation, and/or upregulation of Serpine1, a well-known TGFβ target gene.
|
24306208 |
2014 |
Diabetes Mellitus
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Insulin-mediated translocation of GLUT4 involves the PI3K/Akt kinase signal cascade that results in activation of endothelial NO synthase (eNOS). eNOS is dysfunctional during diabetes.
|
24157451 |
2014 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
However, it's still not clear whether mTOR, another main gene in PI3K/Akt pathway, is also involved in the renal lipogenesis of diabetes.
|
23827786 |
2013 |