Endometriosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Functional analysis revealed several important pathways such as MAPK signaling pathway, and PI3K-AKT signaling pathway, which might be associated with the pathogenesis and development of endometriosis.
|
31144476 |
2019 |
Endometriosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our finding suggests aberrant DNA methylation can activate several signaling pathways including PI3k-AKT signaling, relaxin, and oxytocin which are associated with the pathogenesis of endometriosis.
|
31273584 |
2019 |
Endometriosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In both mouse and human ovaries, the PI3K-PTEN-Akt-Foxo3 pathway was activated in samples from endometriosis.
|
31219551 |
2019 |
Endometriosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, the inhibition of the PI3K/Akt/mTOR signaling pathway may alleviate endometriosis-associated sciatic nerve pain in a rat model of sciatic endometriosis.
|
31461309 |
2019 |
Endometriosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our study revealed an increased expression of PI3K in eutopic and ectopic endometrium from patients with endometriosis, and a reduced expression of PTEN and increased levels of AKT phosphorylation, compared to control endometrium.
|
31637941 |
2019 |
Endometriosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Western blot was used to detect the protein expressions of PI3K-Akt in endometriosis and lesion endometriosis.
|
29762822 |
2018 |
Endometriosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
CCL19/CCR7 contributes to the pathogenesis of endometriosis via PI3K/Akt pathway by regulating the proliferation and invasion of ESCs.
|
28856757 |
2017 |
Endometriosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We aimed to investigate EWI-2 expression in endometrium tissues collected from women with endometriosis at mRNA and protein levels, to evaluate its potential as a biomarker for endometriosis and to study its functional role via possible regulation of the PI3K/Akt signaling pathway.
|
28544021 |
2017 |
Endometriosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
IGF-I stimulates ERβ and aromatase expression via IGF1R/PI3K/AKT-mediated transcriptional activation in endometriosis.
|
26899323 |
2016 |
Endometriosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our findings revealed a possible involvement of the PTEN-PI3K/Akt-Bad axis in the pathogenesis of endometriosis, which may facilitate the discovery of suitable pathway inhibitors for disease treatment.
|
24154570 |
2014 |
Endometriosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We found that aberrant PTEN expression and mitogen-activated protein kinases (MAPK)/ERK, phosphoinositide 3-kinase (PI3K)/AKt, and nuclear factor-kappaB (NFkappaB) signaling overactivities coexisted in endometriosis.
|
19932734 |
2010 |
Endometriosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The RAS/RAF/MAPK and PI3K pathways may be involved in initial development of endometriosis.
|
16210010 |
2005 |