Disease: Premature Menopause ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025322
Disease: Premature Menopause
Premature Menopause 		0.060 AlteredExpression disease BEFREE The KTC showed protective potentials of ovarian reserve and fertility to attenuate premature ovarian failure, which was relatively associated with activation of the PI3K/AKT/mTOR signaling pathway. 31009706 2019
CUI: C0025322
Disease: Premature Menopause
Premature Menopause 		0.060 Biomarker disease BEFREE Acupuncture Reduces Apoptosis of Granulosa Cells in Rats with Premature Ovarian Failure Via Restoring the PI3K/Akt Signaling Pathway. 31847241 2019
CUI: C0025322
Disease: Premature Menopause
Premature Menopause 		0.060 Biomarker disease BEFREE Hippo disruption caused by ovarian fragmentation and exposure to PI3K/Akt activators have been successfully used to activate resting follicles prior to grafting in patients with premature ovarian insufficiency. 30032281 2018
CUI: C0025322
Disease: Premature Menopause
Premature Menopause 		0.060 Biomarker disease BEFREE Our data suggest that the PI3K/Akt signal pathway is involved in the recovery of ovarian function by changing the ratios of Th17/ Tc17 and Th17/Treg cells in POF mice following hPMSC transplantation. 29444704 2018
CUI: C0025322
Disease: Premature Menopause
Premature Menopause 		0.060 Biomarker disease BEFREE The suppressed PI3K/AKT signaling and failed DNA damage response signaling probably contribute to large-scale oocyte loss and eventually POF. 29725001 2018
CUI: C0025322
Disease: Premature Menopause
Premature Menopause 		0.060 Biomarker disease BEFREE In conclusion, curcumin effectively inhibited d-gal-induced oxidative stress, apoptosis and ovarian injury via a mechanism involving the Nrf2/HO-1 and PI3K/Akt signaling pathways, suggesting that curcumin is a potential protective agent against POF. 29437881 2018