Oestrogen receptor positive breast cancer
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we present the retrospective analysis of a prospective randomized trial in ER-positive breast cancer on the prognostic and predictive value of specific tumor-associated lymphocytes in the context of PI3K alterations.
|
31391067 |
2019 |
Oestrogen receptor positive breast cancer
|
0.100 |
Biomarker
|
disease |
BEFREE |
Selective phosphatidylinositol 3 kinase (PI3K) inhibitors are being actively tested in clinical trials for ERα-positive (ER+) breast cancer due to the presence of activating PIK3CA mutations.
|
30315845 |
2019 |
Oestrogen receptor positive breast cancer
|
0.100 |
Biomarker
|
disease |
BEFREE |
The strategy of combining endocrine therapy with PI3K-mTOR inhibition has shown promise in estrogen receptor (ER)-positive breast cancer, but new agents and combinations with a better therapeutic index are urgently needed.
|
31439579 |
2019 |
Oestrogen receptor positive breast cancer
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
C4 and C5 were further assessed for their actions against tamoxifen-resistant MCF-7 cells and a patient-derived xenograft triple-negative BC cell line (TU-BcX-4IC) and for their mechanisms of action using selective mitogen-activated protein kinase kinase MEK1/2, MEK5, and phosphoinositide 3-kinase (PI3K) inhibitors.
|
31221824 |
2019 |
Oestrogen receptor positive breast cancer
|
0.100 |
Biomarker
|
disease |
BEFREE |
Higher BARD1 and BRCA1 expression is associated with worse prognosis of early breast cancer patients, especially the ones that received radiotherapy, indicating the potential use of PI3K inhibitors to reverse chemoresistance and radioresistance in ER-positive breast cancer patients.
|
29686231 |
2018 |
Oestrogen receptor positive breast cancer
|
0.100 |
Biomarker
|
disease |
BEFREE |
This review examines the most important PI3K inhibitors in ER positive breast cancer to date, with a particular focus on their role in overcoming endocrine therapy resistance and the possible use of PIK3CA mutations as a predictive biomarker.
|
29252036 |
2018 |
Oestrogen receptor positive breast cancer
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Estrogen receptor alpha drives mTORC1 inhibitor-induced feedback activation of PI3K/AKT in ER+ breast cancer.
|
29507656 |
2018 |
Oestrogen receptor positive breast cancer
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings warrant clinical evaluation of therapeutic strategies to target ER, PI3K, and autophagy for the treatment of ER<sup>+</sup> breast cancer.-Yang, W., Hosford, S. R., Traphagen, N. A., Shee, K., Demidenko, E., Liu, S., Miller, T. W. Autophagy promotes escape from phosphatidylinositol 3-kinase inhibition in estrogen receptor-positive breast cancer.
|
29127189 |
2018 |
Oestrogen receptor positive breast cancer
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recent studies implicate hyperactivation of PI3K/mTOR signaling as promoting resistance to antiestrogen therapies in ER+ breast cancer.
|
28910567 |
2017 |
Oestrogen receptor positive breast cancer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Phosphatidylinositol 3-kinase (PI3K) inhibitors are being developed for the treatment of estrogen receptor α (ER)-positive breast cancer in combination with antiestrogens.
|
26733612 |
2016 |
Oestrogen receptor positive breast cancer
|
0.100 |
Biomarker
|
disease |
BEFREE |
We tested the therapeutic potential of the novel PI3K/mTOR dual inhibitor P7170 in a panel of anti-estrogen-sensitive and anti-estrogen-resistant models of ER+ breast cancer.
|
25491778 |
2015 |
Oestrogen receptor positive breast cancer
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results thus indicated that ER-α36-mediated antiestrogen signaling such as the PI3K/AKT plays an important role in antiestrogen resistance of ER-positive breast cancer stem/progenitor cells.
|
25158023 |
2014 |
Oestrogen receptor positive breast cancer
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
As the class I phosphatidylinositol 3' kinase (PI3K) pathway is frequently activated in ER+ breast cancer and has been linked to acquired resistance to hormonal therapy, we hypothesized pathway status could evolve over time and treatment.
|
24520381 |
2014 |
Oestrogen receptor positive breast cancer
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here we study PIK3CA genotype as well as a previously reported PI3K/mTOR-pathway gene signature (PIK3CA-GS) and their ability to estimate the level of PI3K pathway activation in two clinical trials of newly diagnosed ER-positive breast cancer patients- a total of 81 patients- one of which was randomized between letrozole and placebo vs letrozole and everolimus.
|
23301057 |
2013 |
Oestrogen receptor positive breast cancer
|
0.100 |
Biomarker
|
disease |
BEFREE |
ER and PI3K independently modulate endocrine resistance in ER-positive breast cancer.
|
22096658 |
2011 |
Oestrogen receptor positive breast cancer
|
0.100 |
Biomarker
|
disease |
BEFREE |
The synthetic lethality observed between estrogen deprivation and PI3K pathway inhibition in estrogen receptor positive (ER+) breast cancer cell lines provides further scientific rational to target both estrogen receptor and the PI3K pathway in order to improve the outcome of ER+ breast cancer.
|
21420991 |
2011 |
Oestrogen receptor positive breast cancer
|
0.100 |
Biomarker
|
disease |
BEFREE |
The PI3K catalytic subunit inhibitor BKM120, the mammalian target of rapamycin (mTOR) inhibitor RAD001 and the dual PI3K/mTOR inhibitor BGT226 were tested against ER-positive breast cancer cell lines before and after long-term estrogen deprivation (LTED).
|
21362200 |
2011 |
Oestrogen receptor positive breast cancer
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, the combination of MAPK and PI3K inhibitors represents a promising strategy to overcome endocrine therapy resistance in ER+ breast cancer patients.
|
19609946 |
2010 |
Oestrogen receptor positive breast cancer
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Proteomic and transcriptomic profiling reveals a link between the PI3K pathway and lower estrogen-receptor (ER) levels and activity in ER+ breast cancer.
|
20569503 |
2010 |
Oestrogen receptor positive breast cancer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We therefore sought to examine relationships between pharmacologic inhibition and somatic mutations in PI3K catalytic subunits in estrogen receptor (ER)-positive breast cancer, in which these mutations are particularly common.
|
19366795 |
2009 |
Oestrogen receptor positive breast cancer
|
0.100 |
Biomarker
|
disease |
BEFREE |
Knockdown of the tumor suppressor phosphatase Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) with shRNA in three estrogen receptor (ER)-positive breast cancer cell lines resulted in increased phosphatidylinositol-3 kinase (PI3K) and AKT activities, resistance to tamoxifen and fulvestrant, and hormone-independent growth.
|
19435893 |
2009 |