|
Hypertensive disease
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Additionally, body mass index (BMI), FMD, PKD1 truncating mutation, endothelin and triglyceride levels were independently associated with hypertension.
|
30022320 |
2019 |
|
Hypertensive disease
|
0.200 |
GeneticVariation
|
group |
BEFREE |
We conducted a longitudinal retrospective cohort study to assess the association between sex of the affected parent and time to hypertension diagnosis, end-stage renal disease (ESRD), and death in patients with the PKD1 genotype.
|
29035198 |
2018 |
|
Hypertensive disease
|
0.200 |
GeneticVariation
|
group |
BEFREE |
In the post hoc analysis, PKD1 and PKD2 were screened in 770 subjects and the PROPKD score was calculated in mutation-positive subjects (male: 1 point; hypertension <35 years: 2 points; first urologic event <35 years: 2 points; nontruncating PKD1 mutation: 2 points; truncating PKD1 mutation: 4 points).
|
28992127 |
2018 |
|
Hypertensive disease
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Hypertension and aneurysm are frequently associated with autosomal dominant polycystic kidney disease (ADPKD) caused by polycystin-1 (PC1) mutations, which is closely related to endothelial dysfunction.
|
29472562 |
2018 |
|
Hypertensive disease
|
0.200 |
Biomarker
|
group |
BEFREE |
To elucidate their pathogenesis, we analyzed the cardiac phenotype in Pkd1(cond/cond)Nestin(cre) (CYG+) cystic mice exposed to increased blood pressure, at 5 to 6 and 20 to 24 weeks of age, and Pkd1(+/-) (HTG+) noncystic mice at 5-6 and 10-13 weeks.
|
27475230 |
2016 |
|
Hypertensive disease
|
0.200 |
GeneticVariation
|
group |
BEFREE |
These factors include PKD1 mutation (particularly truncating mutation), men, early onset of hypertension, early and frequent gross hematuria, and among women, three or more pregnancies.
|
24925719 |
2014 |
|
Hypertensive disease
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Prenatal renal cysts (14%), hypertension defined by ambulatory BP (27%) and enlarged kidneys (32%) were observed only in the PKD1 children.
|
19194729 |
2009 |
|
Hypertensive disease
|
0.200 |
Biomarker
|
group |
BEFREE |
In PKD1 median age to hypertension treatment was 46 yr, to CKD stage 3 was 50 yr, to ESRD was 53 yr, and to death was 67 yr.
|
17699277 |
2006 |
|
Hypertensive disease
|
0.200 |
GeneticVariation
|
group |
BEFREE |
ADPKD, often caused by mutations in the PKD1 gene, is associated with life-threatening vascular abnormalities that are commonly attributed to the frequent occurrence of hypertension.
|
15545151 |
2004 |
|
Hypertensive disease
|
0.200 |
GeneticVariation
|
group |
BEFREE |
We conclude that the interaction between the K121Q polymorphism of the PC-1 gene and birth length affects insulin sensitivity and increases susceptibility to type 2 diabetes and hypertension in adulthood.
|
15126519 |
2004 |
|
Hypertensive disease
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Autosomal dominant polycystic kidney disease (ADPKD), often caused by mutations in the PKD1 gene, is associated with life-threatening vascular abnormalities that are commonly attributed to the frequent occurrence of hypertension.
|
10677526 |
2000 |
|
Hypertensive disease
|
0.200 |
GeneticVariation
|
group |
CLINVAR |
|
|
|
|
Hypertensive disease
|
0.200 |
Biomarker
|
group |
HPO |
|
|
|
|
Hypertensive disease
|
0.200 |
CausalMutation
|
group |
CLINVAR |
|
|
|