|
Skin Carcinogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
<b>Methods</b>: We established experiments with wildtype and <i>Lgr5-CreER; Pten<sup>flox/flox</sup></i> mice, and used DMBA/TPA two-stage skin carcinogenesis model to explore the effect of <i>Pten</i> loss in Lgr5<sup>+</sup> HFSCs of 3 weeks old mice in skin carcinogenesis.
|
31754399 |
2019 |
|
Skin Carcinogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Finally, we observed that marliolide significantly inhibited the papilloma formation in DMBA/TPA-induced mouse skin carcinogenesis model and this event was closely associated with lowering the formation of 8-OH-G and 4-HNE in vivo.
|
29525432 |
2018 |
|
Skin Carcinogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, Sos1 disruption delayed the onset of tumor initiation, decreased tumor growth, and prevented malignant progression of papillomas in a DMBA (7,12-dimethylbenz[α]anthracene)/TPA (12-<i>O</i>-tetradecanoylphorbol-13-acetate)-induced skin carcinogenesis model.
|
29844066 |
2018 |
|
Skin Carcinogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
A novel tubulin inhibitor STK899704 induces tumor regression in DMBA/TPA-induced skin carcinogenesis model.
|
29392819 |
2018 |
|
Skin Carcinogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present study investigates the in vitro anticancer activity of HC and its effect on papillomas induced using a DMBA/TPA skin carcinogenesis mouse model.
|
29674280 |
2018 |
|
Skin Carcinogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present study aims to examine the cytotoxic effect of Daucus carota oil fractions on human epidermal keratinocytes and evaluate the chemopreventive activity of the pentane diethyl ether fraction on DMBA/TPA induced skin carcinogenesis in mice.
|
28073348 |
2017 |
|
Skin Carcinogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
DMBA/TPA skin carcinogenesis studies in mice have shown that Rac1 is required for chemically induced skin papilloma formation.
|
28277539 |
2017 |
|
Skin Carcinogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Accordingly, to investigate the role of the Cenp-r gene in skin carcinogenesis, we subjected Cenp-r<sup>-/-</sup> mice to the 7,12-dimethylbenz(a)anthracene (DMBA)/TPA chemical carcinogenesis protocol and monitored tumor development.
|
28795467 |
2017 |
|
Skin Carcinogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study investigated the anticancer activity of HC against invasive epidermal squamous cell carcinoma cells and evaluated its effect in a DMBA/TPA skin carcinogenesis Balb/c murine model.
|
28872682 |
2017 |
|
Skin Carcinogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Application of in vivo stress using the DMBA/TPA skin carcinogenesis protocol revealed that combined inactivation of E2f7/8 enhanced tumorigenesis and accelerated malignant progression.
|
27452520 |
2017 |
|
Skin Carcinogenesis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These lesions resemble mouse skin tumors induced by the two-stage DMBA/TPA skin carcinogenesis protocol; in this protocol BRAFi accelerates tumor induction.
|
24345644 |
2014 |
|
Skin Carcinogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Overexpression of MnSOD in transgenic mice reduces the incidences and multiplicity of papillomas in a DMBA/TPA skin carcinogenesis model.
|
20454814 |
2012 |
|
Skin Carcinogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, KLF4 knockout led to increased cell proliferation and skin carcinogenesis in a classical DMBA/TPA mouse skin cancer model.
|
22491752 |
2012 |
|
Skin Carcinogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We show that, upon DMBA/TPA-induced skin carcinogenesis, transgenic mice overexpressing ped/pea-15 (Tg(ped/pea-15)) display early development of papillomas and a four-fold increase in papilloma number compared to the nontransgenic littermates (P<0.001).
|
16044159 |
2005 |