PLAU, plasminogen activator, urokinase, 5328

N. diseases: 439; N. variants: 8
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1865903
Disease: Long-tract signs
Long-tract signs 		0.100 Biomarker phenotype HPO
CUI: C4024727
Disease: Impaired epinephrine-induced platelet aggregation
Impaired epinephrine-induced platelet aggregation 		0.100 Biomarker phenotype HPO
CUI: C4703620
Disease: Decreased level of GABA in serum
Decreased level of GABA in serum 		0.100 Biomarker phenotype HPO
CUI: C0034065
Disease: Pulmonary Embolism
Pulmonary Embolism 		0.300 Therapeutic disease CTD_human The phase II urokinase-streptokinase pulmonary embolism trial: a national cooperative study. 1098216 1975
CUI: C0034065
Disease: Pulmonary Embolism
Pulmonary Embolism 		0.300 Biomarker disease CTD_human The phase II urokinase-streptokinase pulmonary embolism trial: a national cooperative study. 1098216 1975
CUI: C0524702
Disease: Pulmonary Thromboembolisms
Pulmonary Thromboembolisms 		0.300 Therapeutic disease CTD_human The phase II urokinase-streptokinase pulmonary embolism trial: a national cooperative study. 1098216 1975
CUI: C0524702
Disease: Pulmonary Thromboembolisms
Pulmonary Thromboembolisms 		0.300 Biomarker disease CTD_human The phase II urokinase-streptokinase pulmonary embolism trial: a national cooperative study. 1098216 1975
CUI: C0007820
Disease: Cerebrovascular Disorders
Cerebrovascular Disorders 		0.300 Therapeutic group CTD_human Intracranial bleeding associated with urokinase therapy for acute ischemic hemispheral stroke. 1265806 1976
CUI: C0241832
Disease: Cerebrovascular Insufficiency
Cerebrovascular Insufficiency 		0.300 Therapeutic disease CTD_human Intracranial bleeding associated with urokinase therapy for acute ischemic hemispheral stroke. 1265806 1976
CUI: C0596298
Disease: Cerebrovascular Occlusion
Cerebrovascular Occlusion 		0.300 Therapeutic disease CTD_human Intracranial bleeding associated with urokinase therapy for acute ischemic hemispheral stroke. 1265806 1976
CUI: C2937358
Disease: Cerebral Hemorrhage
Cerebral Hemorrhage 		0.300 Biomarker phenotype CTD_human Intracranial bleeding associated with urokinase therapy for acute ischemic hemispheral stroke. 1265806 1976
CUI: C0024790
Disease: Paroxysmal nocturnal hemoglobinuria
Paroxysmal nocturnal hemoglobinuria 		0.010 Biomarker disease BEFREE A soluble form of the glycolipid-anchored receptor for urokinase-type plasminogen activator is secreted from peripheral blood leukocytes from patients with paroxysmal nocturnal hemoglobinuria. 1325906 1992
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 AlteredExpression group BEFREE At 2-week intervals the cells were tested on the CAM for metastatic ability and assayed for expression of urokinase-type plasminogen activator (uPA) and the M(r) 92,000 and M(r) 72,000 gelatinase/type IV collagenases, enzymes the expression of which has previously been shown to correlate with tumor cell dissemination. 1327511 1992
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.300 Biomarker disease BEFREE Both the PEA3--AP-1 element, the AP-1 site and the COM are required for efficient phorbol ester induction of transcription from the uPA promoter in the HepG2 hepatoma cell line. 1330539 1992
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.210 Biomarker group BEFREE Both the PEA3--AP-1 element, the AP-1 site and the COM are required for efficient phorbol ester induction of transcription from the uPA promoter in the HepG2 hepatoma cell line. 1330539 1992
CUI: C0338106
Disease: Adenocarcinoma of colon
Adenocarcinoma of colon 		0.010 Biomarker disease BEFREE We first showed that active site-inhibited u-PA could displace endogenous u-PA from the surface of the human colon adenocarcinoma cell line HCT 116. 1648983 1991
CUI: C0003838
Disease: Arterial Occlusive Diseases
Arterial Occlusive Diseases 		0.300 Therapeutic group CTD_human Diagnostic and therapeutic strategies of white clot syndrome. 1713745 1991
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.310 Therapeutic disease CTD_human [Chronic intermittent urokinase therapy in therapy-refractory angina pectoris]. 1730212 1992
CUI: C0002962
Disease: Angina Pectoris
Angina Pectoris 		0.300 Therapeutic phenotype CTD_human [Chronic intermittent urokinase therapy in therapy-refractory angina pectoris]. 1730212 1992
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.390 AlteredExpression group BEFREE Urokinase-type plasminogen activator is expressed in stromal cells and its receptor in cancer cells at invasive foci in human colon adenocarcinomas. 1850957 1991
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 Biomarker group BEFREE Together with previous findings of urokinase-type plasminogen activator and its mRNA being located in fibroblast-like cells in the tumor stroma and mRNA for the urokinase receptor in the cancer cells at invasive foci, these results indicate a complex cooperativity among several cell types in regulation of plasminogen activation in colon cancer. 1855221 1991
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.100 Biomarker disease BEFREE Together with previous findings of urokinase-type plasminogen activator and its mRNA being located in fibroblast-like cells in the tumor stroma and mRNA for the urokinase receptor in the cancer cells at invasive foci, these results indicate a complex cooperativity among several cell types in regulation of plasminogen activation in colon cancer. 1855221 1991
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE Together with previous findings of urokinase-type plasminogen activator and its mRNA being located in fibroblast-like cells in the tumor stroma and mRNA for the urokinase receptor in the cancer cells at invasive foci, these results indicate a complex cooperativity among several cell types in regulation of plasminogen activation in colon cancer. 1855221 1991
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.100 Biomarker disease BEFREE Together with previous findings of urokinase-type plasminogen activator and its mRNA being located in fibroblast-like cells in the tumor stroma and mRNA for the urokinase receptor in the cancer cells at invasive foci, these results indicate a complex cooperativity among several cell types in regulation of plasminogen activation in colon cancer. 1855221 1991
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.100 Biomarker group BEFREE Together with previous findings of urokinase-type plasminogen activator and its mRNA being located in fibroblast-like cells in the tumor stroma and mRNA for the urokinase receptor in the cancer cells at invasive foci, these results indicate a complex cooperativity among several cell types in regulation of plasminogen activation in colon cancer. 1855221 1991