PLG, plasminogen, 5340

N. diseases: 586; N. variants: 34
Disease: Ligneous conjunctivitis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1274789
Disease: Ligneous conjunctivitis
Ligneous conjunctivitis 		0.600 Biomarker disease BEFREE Severe plasminogen (PLG) deficiency causes ligneous conjunctivitis, a rare disease characterized by the growth of fibrin-rich pseudomembranes on mucosal surfaces; gums involvement leads to ligneous gingivitis (LG). 30994256 2019
CUI: C1274789
Disease: Ligneous conjunctivitis
Ligneous conjunctivitis 		0.600 AlteredExpression disease BEFREE Ligneous conjunctivitis is a rare form of chronic recurrent membranous conjunctivitis with reduced plasminogen activity. 30165199 2019
CUI: C1274789
Disease: Ligneous conjunctivitis
Ligneous conjunctivitis 		0.600 Biomarker disease BEFREE Treatment of Ligneous Conjunctivitis Using Topical Plasminogen Therapy in an 8-Week-Old Female Infant. 30180242 2018
CUI: C1274789
Disease: Ligneous conjunctivitis
Ligneous conjunctivitis 		0.600 Biomarker disease BEFREE Adjunctive topical plasminogen application appears to be an effective and safe method of controlling pseudomembrane recurrence in patients with ligneous conjunctivitis. 27065432 2017
CUI: C1274789
Disease: Ligneous conjunctivitis
Ligneous conjunctivitis 		0.600 GeneticVariation disease BEFREE A novel plasminogen gene mutation, deficiency of plasminogen antigen and activity, and anti-plasminogen IgG and IgA antibodies were identified in a patient with adult-onset ligneous conjunctivitis. 25674820 2016
CUI: C1274789
Disease: Ligneous conjunctivitis
Ligneous conjunctivitis 		0.600 Biomarker disease BEFREE Individual treatment of ligneous conjunctivitis included topical plasminogen or heparin eye drops, topical or systemic fresh frozen plasma, and surgical removal of ligneous pseudomembranes, mostly with modest or transient efficacy. 21174000 2011
CUI: C1274789
Disease: Ligneous conjunctivitis
Ligneous conjunctivitis 		0.600 Biomarker disease BEFREE We report a case with both ligneous conjunctivitis and ligneous periodontitis in association with plasminogen type I deficiency. 19689523 2009
CUI: C1274789
Disease: Ligneous conjunctivitis
Ligneous conjunctivitis 		0.600 AlteredExpression disease BEFREE We observed a 3-year-old Italian boy presenting ligneous conjunctivitis and low plasma levels of plasminogen. 17179833 2007
CUI: C1274789
Disease: Ligneous conjunctivitis
Ligneous conjunctivitis 		0.600 Biomarker disease BEFREE Ligneous conjunctivitis (LC) is a rare disease characterized by wood-like pseudomembranes developing on the ocular and extraocular mucosae secondary to plasminogen (PLG) deficiency. 17701212 2007
CUI: C1274789
Disease: Ligneous conjunctivitis
Ligneous conjunctivitis 		0.600 GermlineCausalMutation disease ORPHANET Ligneous conjunctivitis: a clinicopathological, immunohistochemical, and genetic study including the treatment of two sisters with multiorgan involvement. 17701212 2007
CUI: C1274789
Disease: Ligneous conjunctivitis
Ligneous conjunctivitis 		0.600 Biomarker disease BEFREE This work describes a series of nucleotide variations related to genes other than the plasminogen one, found during the genetic characterization of plasminogen defect in two unrelated patients with ligneous conjunctivitis. 16444438 2006
CUI: C1274789
Disease: Ligneous conjunctivitis
Ligneous conjunctivitis 		0.600 AlteredExpression disease BEFREE Plasminogen levels were requested as soon as a diagnosis of ligneous conjunctivitis was suspected. 11931777 2002
CUI: C1274789
Disease: Ligneous conjunctivitis
Ligneous conjunctivitis 		0.600 GeneticVariation disease BEFREE In two unrelated subjects with ligneous conjunctivitis no mutations in the plasminogen gene were identified. 11434676 2001
CUI: C1274789
Disease: Ligneous conjunctivitis
Ligneous conjunctivitis 		0.600 AlteredExpression disease BEFREE Our findings also suggest that the severity of clinical symptoms of ligneous conjunctivitis and its associated complications may depend on the amount of plasminogen functional residual activity. 10233898 1999
CUI: C1274789
Disease: Ligneous conjunctivitis
Ligneous conjunctivitis 		0.600 Biomarker disease BEFREE This study provides direct evidence that plasminogen deficiency is one cause of ligneous conjunctivitis and suggests that plasminogen-deficient mice may be an excellent model for the development of therapeutic strategies for the treatment of this debilitating disease. 9473227 1998
CUI: C1274789
Disease: Ligneous conjunctivitis
Ligneous conjunctivitis 		0.600 Biomarker disease BEFREE Here we report for the first time on homozygous type I Plg deficiency in three unrelated female patients who suffered from ligneous conjunctivitis and additional pseudomembranous lesions of other mucous membranes. 9255907 1997
CUI: C1274789
Disease: Ligneous conjunctivitis
Ligneous conjunctivitis 		0.600 GeneticVariation disease BEFREE In the first girl with ligneous conjunctivitis a homozygous G-->A point mutation was identified in plasminogen exon 7 at position 780 leading to an amino acid exchange (Arg216-->His). 9242524 1997
CUI: C1274789
Disease: Ligneous conjunctivitis
Ligneous conjunctivitis 		0.600 Biomarker disease CTD_human