PLK1, polo like kinase 1, 5347

N. diseases: 253; N. variants: 2
Disease: Glioblastoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.080 AlteredExpression disease BEFREE The above data indicated that magnet and transferrin co-modified nanoparticle enhanced siPLK1 penetration across BBB and increased its anti GBM activity in vivo. 29339188 2018
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.080 Biomarker disease BEFREE PLK1 inhibition induced mitotic catastrophe, G<sub>2</sub>-M cell-cycle arrest, and DNA damage, leading to caspase-mediated apoptosis in glioblastoma cells. 30217967 2018
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.080 Biomarker disease BEFREE Our findings suggest that PLK1 might be a promising target for the treatment of GBMs. 23887645 2013
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.080 Biomarker disease BEFREE Inhibition of polo-like kinase 1 in glioblastoma multiforme induces mitotic catastrophe and enhances radiosensitisation. 23790466 2013
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.080 Biomarker disease BEFREE A high-content small molecule screen identifies sensitivity of glioblastoma stem cells to inhibition of polo-like kinase 1. 24204733 2013
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.080 GeneticVariation disease BEFREE Pediatric Ewing's sarcoma (TC-32), neuroblastoma (IMR32 and KCNR), and glioblastoma (SF188) models were also highly sensitive to PLK1 inhibition. 19887553 2009
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.080 AlteredExpression disease BEFREE The chemical and antisense inhibition of PLCgamma resulted in decreased expression of PLK-1 and reduced cell density in glioma cell lines as well as in a primary culture of a glioblastoma. 12029442 2002
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.080 Biomarker disease BEFREE The highest labelling of PLK-1 was demonstrated in glioblastomas. 11678424 2001