PLK1, polo like kinase 1, 5347

N. diseases: 253; N. variants: 2
Disease: Childhood Osteosarcoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma 		0.090 Biomarker disease BEFREE To investigate the mechanism of PLK1 and MYC in regulating progress of osteosarcoma. 31571905 2019
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma 		0.090 Biomarker disease BEFREE Co-delivery of doxorubicin and recombinant plasmid pHSP70-Plk1-shRNA by bacterial magnetosomes for osteosarcoma therapy. 27822032 2017
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma 		0.090 Biomarker disease BEFREE Pathway integration analysis identified Polo Like Kinase 1 (PLK1)-mediated checkpoint adaptation as critical to the survival of a distinctly aggressive osteosarcoma. 29100308 2017
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma 		0.090 Biomarker disease BEFREE The PEI-Fe-LPMSN delivered siRNA-PLK1 effectively into osteosarcoma cancer cells, leading to cell viability inhibition of 80%, higher compared to the 50% reduction when the same dose of siRNA was delivered by a commercial product, oligofectamine. 24406311 2014
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma 		0.090 Biomarker disease BEFREE PLK1 silencing produced growth inhibition, cell cycle retardation and apoptosis induction in human OS cell lines. 25193492 2014
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma 		0.090 AlteredExpression disease BEFREE PLK1 has been found to be highly expressed in the malignant cells of osteosarcoma. 21399492 2011
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma 		0.090 Biomarker disease BEFREE Our findings reinforce the likelihood of directing against Polo-like kinase 1 as a therapeutic option in the treatment of osteosarcoma. 21822121 2011
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma 		0.090 Biomarker disease BEFREE The development of more potent inhibitors that target PLK1 may open doors to a new range of anti-cancer strategies in osteosarcoma. 20144850 2010
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma 		0.090 Biomarker disease BEFREE Our results indicate that PLK1 is a promising molecular target for pharmacologic intervention in OS. 19725836 2009