|
Heart failure
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
These data also show that the altered SR function in human heart failure cannot be explained by altered protein levels of PLB and SERCA2.
|
8689655 |
1996 |
|
Heart failure
|
0.300 |
Biomarker
|
disease |
BEFREE |
Phospholamban deficiency may prevent such left ventricular dysfunction and its progression to heart failure in some of the animal models with dilated cardiomyopathy.
|
11855657 |
2001 |
|
Heart failure
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
A mutation in the coding region of the phospholamban (PLN) gene (R14del) is identified in families with hereditary heart failure.
|
25923014 |
2015 |
|
Heart failure
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Phospholamban (PLB) inhibits SERCA2 activity and is therefore a potential target to improve the cardiac performance in heart failure.
|
10468529 |
1999 |
|
Heart failure
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The p.Arg14del founder mutation in the gene encoding phospholamban (PLN) is associated with an increased risk of malignant ventricular arrhythmia (VA) and heart failure.
|
29635323 |
2019 |
|
Heart failure
|
0.300 |
Biomarker
|
disease |
BEFREE |
Transgenic PLN(R9C) mice recapitulated human heart failure with premature death.
|
12610310 |
2003 |
|
Heart failure
|
0.300 |
Biomarker
|
disease |
BEFREE |
To clarify whether pVHL is involved in PLN degradation in failing hearts, we used carbonylcyanide <i>m</i>-chlorophenylhydrazone (CCCP), a mitochondrial membrane potential (MMP)-lowering reagent, to mimic the heart failure condition in PLN-expressing HEK293 cells and found that CCCP treatment resulted in PLN degradation and increased interaction between PLN and pVHL.
|
29068413 |
2017 |
|
Heart failure
|
0.300 |
Biomarker
|
disease |
BEFREE |
Mutations and post-translational modifications of PLN may lead to dilated cardiomyopathy (DCM) and heart failure.
|
29501609 |
2018 |
|
Heart failure
|
0.300 |
Biomarker
|
disease |
BEFREE |
The ablation of a muscle-specific sarcoplasmic reticulum Ca2+ ATPase (SERCA2a) inhibitor, phospholamban, rescued the spectrum of phenotypes that resemble human heart failure.
|
10555147 |
1999 |
|
Heart failure
|
0.300 |
Biomarker
|
disease |
BEFREE |
The data demonstrate an association between the dose-dependent inhibition of SERCA2a activity by PLN(wt) and the time of onset of heart failure and show that a weak inhibitor of SERCA2a, PLN(R9C), which is diminished in its ability to modify the level of SERCA2a activity, leads to heart failure despite fast sarcoplasmic reticulum Ca(2+) reuptake.
|
19139388 |
2009 |
|
Heart failure
|
0.300 |
Biomarker
|
disease |
BEFREE |
The potential physiological relevance of PLB function in human heart failure is also covered.
|
9790566 |
1998 |
|
Heart failure
|
0.300 |
Biomarker
|
disease |
BEFREE |
Targeting phospholamban by gene transfer in human heart failure.
|
11864915 |
2002 |
|
Heart failure
|
0.300 |
GeneticVariation
|
disease |
LHGDN |
Transgenic PLN(R9C) mice recapitulated human heart failure with premature death.
|
12610310 |
2003 |
|
Heart failure
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
We envision a self-reinforcing mechanism beginning with phosphomimetic R9C-PLB oxidation and loss of SERCA inhibition, leading to impaired calcium regulation and heart failure.
|
25593317 |
2015 |
|
Heart failure
|
0.300 |
Biomarker
|
disease |
BEFREE |
Abnormalities in two proteins that regulate Ca(2+) handling in myocytes, phospholamban and the voltage-dependent L-type Ca(2+) channel, were also reversed, as was the increased expression of genes that are associated with heart failure.
|
16893886 |
2006 |