PLN, phospholamban, 5350

N. diseases: 90; N. variants: 6
Disease: Chronic atrial fibrillation ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0694539
Disease: Chronic atrial fibrillation
Chronic atrial fibrillation 		0.010 AlteredExpression disease BEFREE Although expression and phosphorylation of the SR Ca<sup>2+</sup>-ATPase type-2a (SERCA2a) regulator phospholamban were unchanged in HFrEF and HFrEF-cAF patients, protein levels of SERCA2a were increased in HFrEF-cAF and sarcolipin expression was decreased in both HFrEF and HFrEF-cAF, likely increasing SR Ca<sup>2+</sup> uptake and load. 30356673 2018