PLP1, proteolipid protein 1, 5354

N. diseases: 160; N. variants: 43
Disease: Demyelinating Diseases ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011303
Disease: Demyelinating Diseases
Demyelinating Diseases 		0.220 Biomarker group BEFREE The balance between cathepsin C and cystatin F controls remyelination in the brain of Plp1-overexpressing mouse, a chronic demyelinating disease model. 28251676 2017
CUI: C0011303
Disease: Demyelinating Diseases
Demyelinating Diseases 		0.220 Biomarker group BEFREE The myelin proteolipid protein (PLP) gene (i.e., the PLP/DM20 gene) has been of some interest because of its role in certain human demyelinating diseases, such as Pelizaeus-Merzbacher disease. 10493736 1999
CUI: C0011303
Disease: Demyelinating Diseases
Demyelinating Diseases 		0.220 Biomarker group RGD Myelin-deficient rat: a point mutation in exon III (A----C, Thr75----Pro) of the myelin proteolipid protein causes dysmyelination and oligodendrocyte death. 2479544 1989