|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our study showed that PML has many similar properties compared with the tumor suppressor, eg, Rb.
|
7780148 |
1995 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In an attempt to get new insights into the function of the wild-type PML protein and to investigate whether it displays an altered expression pattern in neoplasms other than acute promyelocytic leukemia, we stained a large number of normal and neoplastic human tissues with a new murine monoclonal antibody (PG-M3) directed against the amino-terminal region of PML.
|
8952536 |
1996 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Taken together, these data indicate that PML is a tumor growth suppressor in prostate cancer and that Ad-PML may be a potential candidate for human prostate cancer therapy.
|
9157977 |
1997 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Intratumoral injections of MCF-7-induced tumors by high titer Ad-PML suppressed tumor growth in nude mice by about 80%.
|
9583681 |
1998 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In this review, we discuss clinical aspects of PML, the ability of JCV to induce tumors in animal models, and the ability of JCV T-antigen to alter cellular function in vitro.
|
9852278 |
1998 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The PML gene of acute promyelocytic leukemia (APL) encodes a cell-growth and tumor suppressor.
|
10637504 |
1999 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
To determine if the PML gene might be involved in other neoplasias such as lung cancer, PML expression was analyzed by immunohistochemical staining and in situ hybridization.
|
10699936 |
2000 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The emergence of the PML/RARalpha gene may be therapy-related or may represent the exceptional result of a clonal evolution during progression of neoplasia.
|
10867147 |
2000 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
PML, the gene associated with acute promyelocytic leukemia (APL); PML, the target of numerous viral agents; PML, the growth suppressor; PML, the mediator of multiple apoptotic pathways; PML, the tumor suppressor; PML, the protein which epitomizes a novel nuclear structure, the nuclear body; PML, the transcription co-factor.
|
10944585 |
2000 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These findings provide important insight into the mechanism of tumor suppressing function of PML and could allow PML to be included in the pathways responsible for IFN-induced cell growth suppression.
|
11042692 |
2000 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The role of PML in tumor suppression.
|
11832207 |
2002 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The promyelocytic leukemia (PML) protein is a tumor suppressor that is disrupted by the chromosomal translocation t(15;17), a consistent cytogenetic feature of acute promyelocytic leukemia.
|
12080044 |
2002 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Deficient expression of the mouse proto-oncogene PML is associated with tumor immune evasion, occurring through down-regulated expression of genes involved in antigen processing and presentation.
|
12243342 |
2002 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Promyelocytic leukemia protein PML acts as a tumor suppressor, whereas its chimeric mutant promyelocytic leukemia/retinoic acid receptor alpha (PML/RAR alpha) causes acute promyelocytic leukemia (APL).
|
12506013 |
2003 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
An additional role for PML as a regulator of major histocompatibility complex (MHC) class I antigen presentation has been proposed in a murine model, which would account for evasion from host immunity of tumors bearing malfunctioning PML, such as acute promyelocytic leukemia.
|
12506025 |
2003 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The promyelocytic leukemia protein (PML) is a growth/tumor suppressor essential for induction of apoptosis by diverse apoptotic stimuli.
|
12540841 |
2003 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Together these results suggest that local interruption of PML and RARalpha signaling in the skin, together with a systemic retinoid deficiency, initiates a tumor induction pathway that is independent of ras activation.
|
14500356 |
2003 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
PML is a tumor suppressor implicated in leukemia and cancer pathogenesis.
|
14663483 |
2003 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The ability of PML to modulate key suppressive pathways in tumor cells suggests that PML may act as a tumor suppressor.
|
14715247 |
2004 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
For some tumor types, the association between PML expression and tumor stage and grade was analyzed.Statistical tests were two-sided.
|
14970276 |
2004 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
An immunohistochemical study of PML protein in these tumors revealed a disrupted pattern of PML bodies in a nuclear diffuse form, as observed in APL cells.
|
15104675 |
2004 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We therefore assayed the tumor suppressor activities of PML and compared them with those of p53 in four liver cancer cell lines.
|
15529177 |
2005 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Promyelocytic leukemia zinc-finger (PLZF) is a transcriptional repressor and tumor suppressor.
|
16862184 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Therefore, pharmacological inhibition of CK2-induced PML loss could be used to offset tumor establishment.
|
16873055 |
2006 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
PML is a tumour suppressor inactivated in Acute Promyelocytic Leukaemia (APL).
|
17503350 |
2007 |