|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The multitasking promyelocytic leukemia (PML) protein was originally recognized as a tumor-suppressive factor, but more recent evidence has implicated PML in tumor cell prosurvival actions and poor patient prognosis in specific cancer settings.
|
30927552 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Recently an unexpected role for the tumor suppressor promyelocytic leukemia protein (PML) in hematopoietic stem cell biology and metabolism regulation has come to light, but its role in MSC biology remains unknown.
|
30082750 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The lack of the tumor suppressor promyelocytic leukemia protein (PML) in combination with HCV fosters hepatocarcinogenesis via induction of HCC using diethylnitrosamine (DEN) in a rodent model.
|
31144474 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The role of PML in tumor suppression has been extensively studied but increasing evidence indicates that PML also plays versatile roles in stem cell renewal, metabolism, inflammatory responses, neural function, mammary development and angiogenesis.
|
29416846 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The immunohistochemistry showed that the promyelocytic leukemia protein (PML, a tumor suppressor involved in genome maintenance and fatty acid oxidation), being inversely influenced by the dynamic HBsAg levels from acute phase to seroclearance, appeared as a lipo-metabolic switch linking HBsAg-induced steatosis (lipogenesis) to HBsAg-lost fat-burning hepatocarcinogenesis (lipolysis).
|
29684791 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Correction to: PML: Regulation and multifaceted function beyond tumor suppression.
|
29528047 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Clinically, the dominant negative PML-RARα fusion protein expressed in acute promyelocytic leukemia (APL) inhibits the transactivation of downstream factors and disrupts PML function, revealing the tumor suppressor role of PML-NBs.
|
28521962 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The PML gene is known as a tumor suppressor and growth regulator in cancer.
|
29114882 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The <i>promyelocytic leukemia</i> (<i>pml</i>) gene product PML is a tumor suppressor localized mainly in the nucleus of mammalian cells.
|
29888200 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The findings demonstrated that PML(NLS‑) was detectable in the cytoplasm of NB4‑HA‑NE cells, the tumors in nude mice and in neutrophils from patients with APL.
|
28849126 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
However, the precise role of the APL-associated PML-RARα oncoprotein and PML-NB integrity in the DSB response in APL leukemogenesis and tumor suppression is still lacking.
|
27468685 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Promyelocytic leukemia (PML) is a tumor suppressor and proapoptotic factor.
|
26703467 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Promyelocytic leukemia (PML) plays a tumor suppressive role by inducing cellular senescence in response to oncogenic stress.
|
27206849 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Here, we provide evidence that the tumor suppressor promyelocytic leukemia protein (PML) controls autophagosome formation at mitochondria-associated membranes (MAMs) and, thus, autophagy induction.
|
27545895 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The promyelocytic leukemia protein PML acts as a tumor suppressor by forming transcription-regulatory complexes with a variety of repressor proteins.
|
25892518 |
2015 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In order to cast light in the mechanism by which PML protein is under-expressed in gastric cancer cells, we analyzed all exons and intron-exon boundaries of PML gene in 50 formalin-fixed paraffin-embedded tissue blocks from gastric carcinoma tumors by means of PCR-SSCP and CSGE, with direct sequencing of abnormally shifted bands.
|
25921172 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Promyelocytic leukemia zinc finger (PLZF) acts as a tumor-suppressor gene in a series of cancers including prostate, melanoma, colon cancer and leukemia.
|
25369784 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The promyelocytic leukemia protein (PML) is a tumor suppressor that is expressed at a low level in various cancers.
|
25032863 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The tumor suppressor promyelocytic leukemia protein (PML) is predominantly localized in the nucleus, where it is essential for the formation and stabilization of the PML nuclear bodies (PML-NBs).
|
24288198 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Promyelocytic leukemia protein (PML) is emerging as an important tumor suppressor.
|
25486572 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In contrast, our IHC analyses of human sarcomas identified a subset of tumors with some cells containing ALT-associated PML bodies, a hallmark of ALT, and separate cells expressing telomerase in the same tumor.
|
23260199 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Among many others, PML has also been established to mediate its tumor suppressive role by mitigating the inactivation of active AKT (pAKT) inside the nucleus by assembling a dephosphorylating platform for nuclear pAKT.
|
23492774 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Promyelocytic leukemia protein (PML) is a tumor suppressor, which is lost in various cancers including lung cancer.
|
23563092 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We analyzed GBM cell lines, patient-derived tumor cell cultures, and clinical samples from patients in phase 1 clinical trials, and find that the promyelocytic leukemia (PML) gene mediates resistance to mTOR-targeted therapies.
|
23440206 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Downregulation of tumor suppressor gene PML in uterine cervical carcinogenesis: impact of human papillomavirus infection (HPV).
|
23220564 |
2013 |