Disease: Hypothyroidism ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020676
Disease: Hypothyroidism
Hypothyroidism 		0.020 Biomarker disease BEFREE This is the first report of human OATP1C1 deficiency compatible with brain-specific hypothyroidism and neurodegeneration. 30296914 2018
CUI: C0020676
Disease: Hypothyroidism
Hypothyroidism 		0.020 Biomarker disease BEFREE One explanation for this discrepancy could be differences in expression of the T4 transporter OATP1C1 in the blood-brain barrier; OATP1C1 is more abundant in rodents than in primates and permits the passage of T4 in the absence of T3 transport, thus preventing full cerebral hypothyroidism. 25942657 2015