|
Chronic Lymphocytic Leukemia
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.
|
23770605 |
2013 |
|
Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Importantly, CyPJ is upregulated in hepatocellular carcinoma (HCC) and promotes tumor growth; CyPJ inhibition by CsA- or siRNA-based knockdown results in a remarkable suppression of HCC.
|
29520233 |
2018 |
|
Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Expression of cyclophilin J was associated with the degree of differentiation, but not with lymph node metastasis, gender or depth of tumor infiltration.
|
28739742 |
2017 |
|
Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
CYPJ overexpression accelerated liver cell growth in vitro (cell growth assay, colony formation) and in vivo (xenograft tumor formation).
|
26020957 |
2015 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
However, apart from the common inhibitor CsA, CyPJ has yet to be investigated as a target for cancer therapy.
|
29520233 |
2018 |
|
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
|
0.020 |
Biomarker
|
disease |
BEFREE |
Differential Proteomic Analysis Reveals Protein Networks and Pathways that May Contribute to Helicobacter pylori FKBP-Type PPIase-Associated Gastric Diseases.
|
29148176 |
2018 |
|
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
However, apart from the common inhibitor CsA, CyPJ has yet to be investigated as a target for cancer therapy.
|
29520233 |
2018 |
|
Liver carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
These findings suggest that CyPJ may be a potential therapeutic target for HCC, and discovery of relevant inhibitors may facilitate development of a novel CyPJ-based targeting therapy.
|
29520233 |
2018 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Suppression of CYPJ could repress the growth of HCC, which makes CYPJ a potential target for the development of new strategies to treat this malignancy.
|
26020957 |
2015 |
|
Glioma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Cyclophilin J (CYPJ) is a new member of the peptidyl-prolyl cis/trans-isomerase (PPIase) identified with upregulated expression in human glioma.
|
26020957 |
2015 |
|
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
|
0.020 |
Biomarker
|
disease |
BEFREE |
Helicobacter pylori FKBP-type PPIase promotes gastric epithelial cell proliferation and anchorage-independent growth through activation of ERK-mediated mitogenic signaling pathway.
|
25687921 |
2015 |
|
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
Suppression of CYPJ could repress the growth of HCC, which makes CYPJ a potential target for the development of new strategies to treat this malignancy.
|
26020957 |
2015 |
|
Liver carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
CYPJ was found expressed in the whole cell of HCC with preferential location at the cell nucleus.
|
26020957 |
2015 |
|
Glioma
|
0.020 |
Biomarker
|
disease |
BEFREE |
The novel full-length gene of human PPIL3 may be correlated with the formation of human glioma.
|
15989758 |
2005 |
|
Glioma
|
0.020 |
Biomarker
|
disease |
LHGDN |
The novel full-length gene of human PPIL3 may be correlated with the formation of human glioma.
|
15989758 |
2005 |
|
Parkinson Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
The PPIase CypA colocalizes with the Parkinson's disease (PD)-associated protein α -synuclein in cells and interacts with α -synuclein oligomers.
|
31830361 |
2020 |
|
Abscess
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Previously, we identified two PPIase enzymes in <i>Staphylococcus aureus</i> (PpiB and PrsA) that are involved in the regulation of virulence determinants and have shown that PpiB contributes to <i>S. aureus</i> virulence in a murine abscess model of infection.
|
31208155 |
2019 |
|
Stomach Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Our results provided insight on the protein interaction networks and signaling pathways that may contribute to PPIase-FKBP-associated gastric diseases and may lead to a better understanding of the mechanisms indicating the oncogenic effects of H. pylori PPIase-FKBP.
|
29148176 |
2018 |
|
Arthritis aggravated
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our findings provide evidence that PPIase CypA promoted macrophages polarization toward pro-inflammatory M1 phenotype via transcriptional activating NF-κB, thus leading to aggravated arthritis.
|
28756520 |
2017 |
|
Gastric Adenocarcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Expression and Significance of Cyclophilin J in Primary Gastric Adenocarcinoma.
|
28739742 |
2017 |
|
Secondary malignant neoplasm of lymph node
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Expression of cyclophilin J was associated with the degree of differentiation, but not with lymph node metastasis, gender or depth of tumor infiltration.
|
28739742 |
2017 |
|
estrogen receptor-negative breast cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
Using functional and eQTL studies we implicate TRMT61B and WDR43 at 2p23.2 and PPIL3 at 2q33 in ER-negative breast cancer aetiology.
|
27117709 |
2016 |
|
Adult Liver Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Inhibition of CYPJ by its inhibitor CsA or CYPJ-specific RNAi diminished the growth of liver cancer cells in vitro and in vivo.
|
26020957 |
2015 |
|
Liver and Intrahepatic Biliary Tract Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Inhibition of CYPJ by its inhibitor CsA or CYPJ-specific RNAi diminished the growth of liver cancer cells in vitro and in vivo.
|
26020957 |
2015 |
|
Malignant neoplasm of liver
|
0.010 |
Biomarker
|
disease |
BEFREE |
Inhibition of CYPJ by its inhibitor CsA or CYPJ-specific RNAi diminished the growth of liver cancer cells in vitro and in vivo.
|
26020957 |
2015 |