PRRX1, paired related homeobox 1, 5396

N. diseases: 134; N. variants: 11
Disease: Fibrosis, Liver ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver 		0.040 AlteredExpression disease BEFREE Thus, the relative dynamic levels of Gm11149 and Ncam1, Gm20471 and Prrx1 were further monitored during the progress of liver fibrosis and their co-expression pattern was proved. 30193772 2018
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver 		0.040 Biomarker disease BEFREE These studies reveal a role of Prrx1 as a modulator of PDGF-dependent signaling in HSCs, and inhibiting its expression may offer a therapeutic approach for hepatic fibrosis. 28737764 2017
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver 		0.040 Biomarker disease BEFREE This is the first description of the effects of Prx1 in HSCs and in the liver, and identification of the two Prx1 target genes, which play a pivotal role in development of liver fibrosis, is a novel finding for liver pathophysiology. 18296734 2008
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver 		0.040 AlteredExpression disease BEFREE RNA-binding protein RBMS3 is expressed in activated hepatic stellate cells and liver fibrosis and increases expression of transcription factor Prx1. 17586524 2007