|
Alopecia Areata
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Increased expression of TLR7 and TLR9 in alopecia areata.
|
31571275 |
2020 |
|
Trichotillomania
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Notably, TLR9 was most significantly upregulated in patients with active AA, as shown by a positive hair pull test, compared to stable AA patients.
|
31571275 |
2020 |
|
Lung Diseases, Interstitial
|
0.010 |
Biomarker
|
group |
BEFREE |
Neutrophil extracellular traps activate lung fibroblast to induce polymyositis-related interstitial lung diseases via TLR9-miR-7-Smad2 pathway.
|
31821687 |
2020 |
|
progesterone receptor-negative breast cancer
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In addition, TLR3 and TLR9 displayed significantly different expression levels in ER‑/PR‑negative breast cancer compared with the control tissues, while TLR5 expression was significantly reduced in HER2‑enriched breast cancer.
|
31789409 |
2020 |
|
Adenocarcinoma
|
0.010 |
Biomarker
|
group |
BEFREE |
The aim of the study was to evaluate the clinical significance of tissue expression and serum concentration of TLR-2, TLR-4, TLR-7 and TLR-9 in patients with esophageal squamous cell carcinoma and gastro-esophageal junction adenocarcinoma.
|
29968427 |
2019 |
|
Uterine Cervicitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
TLR4 and TLR9 polymorphisms, as well as haplotypes were shown to modulate the cervicitis risk.
|
31365550 |
2019 |
|
Leishmaniasis, Cutaneous
|
0.010 |
Biomarker
|
disease |
BEFREE |
Together, these results suggest that TLR9 contributes to C57BL/6 mouse resistance against L. amazonensis, and that the TLR9-binding LaAg comprising CpG motifs may be important for intranasal vaccine efficacy against CL.
|
30802247 |
2019 |
|
Leukoplakia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The genotypic association of TLR 9(-1486T/C) in OSMF cases showed ˜8 fold increased risk and TLR 4(+896A/G) showed fourteen fold higher risk for leukoplakia (p < 0.0001, OR = 14.000).
|
31129425 |
2019 |
|
Liver diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
There were no consistent association between TLR9 polymorphisms and spontaneous clearance of HBV, however, a significant association was observed between rs187084 AA genotype and HBV progression to advanced liver disease.
|
30453064 |
2019 |
|
Myocarditis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The data suggest that interfering TLR9-IRF5 pathway could be an approach to treat CVB3-induced myocarditis.
|
31279856 |
2019 |
|
Neuralgia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Macrophage Toll-like Receptor 9 Contributes to Chemotherapy-Induced Neuropathic Pain in Male Mice.
|
31270160 |
2019 |
|
Neuromyelitis Optica
|
0.010 |
Biomarker
|
disease |
BEFREE |
High frequency of circulating Th17 cell subsets expressing TLR2, TLR4 and TLR9 was observed in Neuromyelitis optica spectrum disorder (NMOSD) patients, a severe humoral autoimmune disease of the central nervous system.
|
31229737 |
2019 |
|
Kaposi Sarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our data show that UNC93B-dependent TLR7 and TLR9 cooperate in and contribute to detection and control of MHV68 infection.<b>IMPORTANCE</b> The two human gammaherpesviruses, Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV), can cause aggressive forms of cancer.
|
30429335 |
2019 |
|
Silicosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Such requirement was further observed in inflammatory models where DNA sensing via TLR9 contributes to disease, such as silicosis and drug-induced liver injury.
|
31836766 |
2019 |
|
Thrombocytopenia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Our findings uncover a mechanism by which TLR7 and TLR9 specify monocyte fate and identify a specialized population of phagocytes responsible for anemia and thrombocytopenia associated with inflammation and infection.
|
30630901 |
2019 |
|
Acute leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
<b>Methods</b>: The Therapeutic Advances in Childhood Leukemia and Lymphoma Phase I consortium performed a pilot study on 3 patients with MRD positive acute leukemia after an initial remission on conventional chemotherapy (TACL T2009-008) with the TLR 9 agonist (GNKG168).
|
31530240 |
2019 |
|
Chronic gastritis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
For TLR9-1486, an association between the CT + TT genotypes and increased risk of both GC (dominant model OR = 2.72, 95%CI: 1.57-4.72, <i>P</i> < 0.0001) and CG (dominant model OR = 1.79, 95%CI: 1.15-2.79, <i>P</i> = 0.0094) was observed when compared to the C group.
|
31798780 |
2019 |
|
Glaucomatocyclitic crisis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The purpose of this study was to investigate whether single nucleotide polymorphisms (SNPs) of TLR2, TLR3, TLR4 and TLR9 genes are associated with susceptibility to presumed viral-induced anterior uveitis (PVIAU) and Posner-Schlossman syndrome (PSS).
|
31465768 |
2019 |
|
Secondary malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
TLR9 agonist enhances radiofrequency ablation-induced CTL responses, leading to the potent inhibition of primary tumor growth and lung metastasis.
|
30467420 |
2019 |
|
Metastatic malignant neoplasm to brain
|
0.010 |
Biomarker
|
disease |
BEFREE |
Prophylactic TLR9 stimulation reduces brain metastasis through microglia activation.
|
30921319 |
2019 |
|
Papillary thyroid carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Induced expression of Tlr9 in ECs correlates with PTC injury and the development of TILs in lupus-prone AGN model mice.
|
30813872 |
2019 |
|
Neoplasm, Residual
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The TLR9 agonist (GNKG168) induces a unique immune activation pattern in vivo in children with minimal residual disease positive acute leukemia: Results of the TACL T2009-008 phase I study.
|
31530240 |
2019 |
|
Organ dysfunction syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
These studies suggest that intestinal TLR9 activation protects against ischemic AKI and associated remote multi-organ dysfunction syndrome by regulating Paneth cell IL-17A synthesis.
|
30777286 |
2019 |
|
Prediabetes syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
However, IL-33 was not associated with any of these mediators but was directly and strongly associated with TLR9 in individuals with prediabetes.
|
31073344 |
2019 |
|
Bacterial sepsis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Membrane TLR9 Positive Neutrophil Mediated MPLA Protects Against Fatal Bacterial Sepsis.
|
31534550 |
2019 |