TLR9, toll like receptor 9, 54106

N. diseases: 457; N. variants: 11
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.360 GeneticVariation disease UNIPROT
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 AlteredExpression group BEFREE Tumor-induced down-regulation of toll-like receptor 9 was identified as one mechanism likely contributing to impaired PDC function within the tumor environment. 14559840 2003
CUI: C0018188
Disease: Granuloma
Granuloma 		0.010 AlteredExpression phenotype LHGDN Associations between toll-like receptors and interleukin-4 in the lungs of patients with tuberculosis. 12600829 2003
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.370 Biomarker disease CTD_human Crohn's disease is associated with a toll-like receptor-9 polymorphism. 15236225 2004
CUI: C0156147
Disease: Crohn's disease of large bowel
Crohn's disease of large bowel 		0.300 Biomarker disease CTD_human Crohn's disease is associated with a toll-like receptor-9 polymorphism. 15236225 2004
CUI: C0267380
Disease: Crohn's disease of the ileum
Crohn's disease of the ileum 		0.300 Biomarker disease CTD_human Crohn's disease is associated with a toll-like receptor-9 polymorphism. 15236225 2004
CUI: C0678202
Disease: Regional enteritis
Regional enteritis 		0.300 Biomarker disease CTD_human Crohn's disease is associated with a toll-like receptor-9 polymorphism. 15236225 2004
CUI: C0949272
Disease: IIeocolitis
IIeocolitis 		0.300 Biomarker disease CTD_human Crohn's disease is associated with a toll-like receptor-9 polymorphism. 15236225 2004
CUI: C0024530
Disease: Malaria
Malaria 		0.100 Biomarker disease BEFREE Malaria blood stage parasites activate human plasmacytoid dendritic cells and murine dendritic cells through a Toll-like receptor 9-dependent pathway. 15067072 2004
CUI: C0042769
Disease: Virus Diseases
Virus Diseases 		0.100 AlteredExpression group BEFREE Plasmacytoid dendritic cells, activated by bacterial antigens via TLR9 or by viral infection, did not produce the protein. 14688085 2004
CUI: C0024535
Disease: Malaria, Falciparum
Malaria, Falciparum 		0.020 Biomarker disease BEFREE These results demonstrate that schizont extracts contain a novel and previously unknown ligand for TLR9 and suggest that the stimulatory effects of this ligand on PDCs may play a key role in immunoregulation and immunopathogenesis of human falciparum malaria. 15067072 2004
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.370 Biomarker disease BEFREE Synergy between TLR9 and NOD2 innate immune responses is lost in genetic Crohn's disease. 15928043 2005
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.370 AlteredExpression disease BEFREE TLR9 mRNA was equally expressed in colonic mucosa from controls (n = 6) and patients with ulcerative colitis or Crohn's disease disease (n = 13). 15996194 2005
CUI: C0004096
Disease: Asthma
Asthma 		0.100 GeneticVariation disease BEFREE Recently, a possible association of TLR9 polymorphism C-1237T with asthma has been reported. 16164440 2005
CUI: C0004096
Disease: Asthma
Asthma 		0.100 Biomarker disease BEFREE Our results indicate that 1) phenotype spread to the neo-allergen can be induced only within the first 8 h after a bronchial challenge with the first Ag (OVA); 2) Th2 differentiation of naive CD4(+) T cells occurs in bronchial lymph nodes; 3) trafficking of naive CD4(+) T cells to local lymph nodes and IL-4 produced by OVA-activated Th2 cells play essential roles in the differentiation of naive CD4(+) T cells to Th2 cells; and 4) suppression of the production of chemokines involved in the homing of naive CD4(+) T and Th2 cells to bronchial lymph nodes by a TLR9 agonist inhibited phenotype spread and abrogated the consequent development of experimental asthma. 15843591 2005
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases 		0.100 Biomarker group BEFREE TLR9 is potentially associated with autoimmune diseases, because it participates in the production of pro-inflammatory cytokines and the maturation of dendritic cells. 15730519 2005
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases 		0.100 Biomarker group BEFREE These results demonstrate a specific requirement for TLR9 in autoantibody formation in vivo and indicate a critical role for innate immune activation in autoimmunity. 16027240 2005
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 AlteredExpression group BEFREE In this study, we report that H. pylori-induced COX-2 expression enhances the cancer cell invasion and angiogenesis via TLR2 and TLR9, which can be attenuated by the specific COX-2 inhibitor NS398 or celecoxib. 16339564 2005
CUI: C0023434
Disease: Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia 		0.100 AlteredExpression disease BEFREE Consistent with CpG oligodeoxynucleotides sensitivity, TLR9 mRNA was present in B-CLL but absent in plasmacytoma. 15746051 2005
CUI: C0024131
Disease: Lupus Vulgaris
Lupus Vulgaris 		0.100 Biomarker disease BEFREE We show that in TLR9-deficient lupus-prone mice, the generation of anti-dsDNA and antichromatin autoantibodies is specifically inhibited. 16027240 2005
CUI: C0024138
Disease: Lupus Erythematosus, Discoid
Lupus Erythematosus, Discoid 		0.100 Biomarker disease BEFREE We show that in TLR9-deficient lupus-prone mice, the generation of anti-dsDNA and antichromatin autoantibodies is specifically inhibited. 16027240 2005
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.100 GeneticVariation disease BEFREE TLR9 gene polymorphisms were not significantly associated with the susceptibility to SLE and related phenotypes. 15730519 2005
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.100 Biomarker disease BEFREE We show that in TLR9-deficient lupus-prone mice, the generation of anti-dsDNA and antichromatin autoantibodies is specifically inhibited. 16027240 2005
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 AlteredExpression group BEFREE The use of nude mice excluded a T cell-mediated immune response, whereas the high pancreatic expression of TLR9 might have contributed to the tumor response. 16024642 2005
CUI: C0409974
Disease: Lupus Erythematosus
Lupus Erythematosus 		0.100 Biomarker disease BEFREE We show that in TLR9-deficient lupus-prone mice, the generation of anti-dsDNA and antichromatin autoantibodies is specifically inhibited. 16027240 2005