Lupus Erythematosus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Toll-like receptor 9 in murine lupus: more friend than foe!
|
18241699 |
2008 |
Lupus Erythematosus
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
TLR9 expression was positively correlated with fever (P = 0.017), alopecia (P = 0.046), safety of estrogens in lupus erythematosus national assessment SLE disease activity index (SELENA-SLEDAI) score (r(s) = 0.385, P = 0.003), and the level of IRF5 (r(s) = 0.35, P = 0.027) and IFN-a (r(s) = 0.627, P = 0.001) in SLE patients.
|
22932083 |
2012 |
Lupus Erythematosus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Toll-like receptor 9 suppresses lupus disease in Fas-sufficient MRL Mice.
|
28278279 |
2017 |
Lupus Erythematosus
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
African American women with lupus had a 2-fold increase in TLR-9 expression level when compared to their healthy controls or European American lupus patients.
|
24865418 |
2014 |
Lupus Erythematosus
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
And the increase of the co-expression of TLR9 and T-bet may be of benefit to the protective antibodies' production and pathogenic antibodies' decline, and could be regarded as a good sign for lupus demission and/or treatment.
|
19362685 |
2009 |
Lupus Erythematosus
|
0.100 |
Biomarker
|
disease |
BEFREE |
DNA-containing immune complexes purified from sera of patients with lupus induced TLR-9 in cultured proximal tubular cells.
|
17469139 |
2007 |
Lupus Erythematosus
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Hence, this study was carried out to analyze the G to A and C to T transitions in TLR2 and TLR9 genes respectively and to test their association with lupus susceptibility, clinical and autoantibody phenotypes in South Indian Tamils.
|
25466615 |
2015 |
Lupus Erythematosus
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this review, we discuss the rationale for self-recognition by TLR7 and TLR9 as an important part of the development of lupus and other autoimmune diseases.
|
18613842 |
2008 |
Lupus Erythematosus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our observations provide new insights about the MZ B cell translocation in lupus patients as well as the dichotomy of TLR9 and TLR7 signals in the pathogenesis of lupus.
|
30286201 |
2018 |
Lupus Erythematosus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Role of TLR9 has been elegantly demonstrated in both human systemic lupus erythematosus (SLE) and mice model of lupus.
|
23974051 |
2013 |
Lupus Erythematosus
|
0.100 |
Biomarker
|
disease |
BEFREE |
The ability of TLR9 to detect and elicit an immune response against double-stranded DNA makes TLR9 a relevant factor to be tested for its association with the clinical and serological phenotypes of lupus.
|
27432810 |
2017 |
Lupus Erythematosus
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These findings suggest a unique link between neutrophils and B cells in which NETs trigger a concerted activation of TLR9 and BCR leading to anti-NET autoantibody production in lupus.
|
29632142 |
2018 |
Lupus Erythematosus
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results demonstrate that both TLR9 and TLR4 are required for 'full-blown' autoimmunity and organ injury in experimental lupus induced by pristane.
|
20810248 |
2010 |
Lupus Erythematosus
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that up-regulated expression of TLR7 and TLR9 mRNAs together with increased expression of IFN-alpha mRNA in PBMCs may also contribute to the pathogenesis of human lupus.
|
18373699 |
2008 |
Lupus Erythematosus
|
0.100 |
Biomarker
|
disease |
BEFREE |
This finding together with reduced cytokine production upon TLR9 activation appears to mark postactivated lupus B cells.
|
30540579 |
2019 |
Lupus Erythematosus
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study was undertaken to examine the suppressive role of TLR-9 in the development of severe lupus in a mouse model.
|
29687651 |
2018 |
Lupus Erythematosus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, IFN-I signaling is an important mediator of lupus pathogenesis and anti-RNA Ab production that is dysregulated in the absence of Tlr9.
|
23467932 |
2013 |
Lupus Erythematosus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus.
|
16973389 |
2006 |
Lupus Erythematosus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Treatment of lupus-prone mice with a dual inhibitor of TLR7 and TLR9 leads to reduction of autoantibody production and amelioration of disease symptoms.
|
18034431 |
2007 |
Lupus Erythematosus
|
0.100 |
Biomarker
|
disease |
BEFREE |
We show that in TLR9-deficient lupus-prone mice, the generation of anti-dsDNA and antichromatin autoantibodies is specifically inhibited.
|
16027240 |
2005 |