|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We show that TLR9 activation by CpG A suppresses IL-33-mediated AHR and airway inflammation through inhibition of ILC2s.
|
30914379 |
2019 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Asthmatics had significantly lower circulating HPC expressing TLR-2 and TLR-9 with a similar trend for TLR-4.
|
28252235 |
2017 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Polymorphisms in the identified chitin receptors, NOD2 and TLR9, predispose individuals to inflammatory conditions and dysregulated expression of chitinases and chitinase-like binding proteins, whose activity is essential to generate IL-10-inducing fungal chitin particles in vitro, have also been linked to inflammatory conditions and asthma.
|
24722226 |
2014 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Although rs5743836 confers regulatory effects on TLR9 transcription, this variant does not appear to be an important asthma-susceptibility locus.
|
21324137 |
2011 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In the on-treatment group, TLR1, TLR2, TLR6, and TLR9 expressions on PBMCs were significantly different between asthmatics and controls.
|
20072849 |
2010 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
CpG oligodeoxynucleotides as TLR9 agonists: therapeutic application in allergy and asthma.
|
20623989 |
2010 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genetic variations within human TLR9 have been reported to be associated with a range of immune-related diseases, such as asthma, systemic lupus erythematosus (SLE) and so on.
|
19130296 |
2009 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To study whether single nucleotide polymorphisms (SNPs) in CD14 and Toll-like receptor (TLR) 2, TLR4 and TLR9 genes are associated with asthma in adults, and whether these SNPs modify associations between country living and asthma.
|
19096003 |
2009 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
It was concluded that TLR9 and CD14 gene polymorphisms may contribute to an inherited predisposition to asthma in Tunisian children.
|
18312481 |
2008 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
It was concluded that TLR9 and CD14 gene polymorphisms may contribute to an inherited predisposition to asthma in Tunisian children.
|
18312481 |
2008 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recently, a possible association of TLR9 polymorphism C-1237T with asthma has been reported.
|
16164440 |
2005 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results indicate that 1) phenotype spread to the neo-allergen can be induced only within the first 8 h after a bronchial challenge with the first Ag (OVA); 2) Th2 differentiation of naive CD4(+) T cells occurs in bronchial lymph nodes; 3) trafficking of naive CD4(+) T cells to local lymph nodes and IL-4 produced by OVA-activated Th2 cells play essential roles in the differentiation of naive CD4(+) T cells to Th2 cells; and 4) suppression of the production of chemokines involved in the homing of naive CD4(+) T and Th2 cells to bronchial lymph nodes by a TLR9 agonist inhibited phenotype spread and abrogated the consequent development of experimental asthma.
|
15843591 |
2005 |