For TLR9-1486, an association between the CT + TT genotypes and increased risk of both GC (dominant model OR = 2.72, 95%CI: 1.57-4.72, <i>P</i> < 0.0001) and CG (dominant model OR = 1.79, 95%CI: 1.15-2.79, <i>P</i> = 0.0094) was observed when compared to the C group.
In conclusion, our study suggests that alterations of flaA protein, moderate motility in <i>H. pylori</i> and two polymorphisms in TLR5 and TLR9 may favor the onset of AAG and GC, at least in a subset of patients.
The genomic DNA of toll-like receptor (TLR) 2, TLR4, radioprotective 105, TLR6, and TLR9 were examined for mutations in 48 patients with gastric cancer.