Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
TLR9 in DCs mediated IL-17A production in γδT cells during sepsis and contributed to the development of septic AKI.
|
31760767 |
2020 |
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Depletion of either TLR9 or Cav-1 largely eliminates the neutrophil-mediated InP effect in sepsis models <i>in vitro</i> and <i>in vivo</i>.
|
31534550 |
2019 |
Septicemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
There is a relationship between sepsis-induced immunosuppression and serum TLR-9 levels.
|
30348730 |
2019 |
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we found an unexpected major role of TLR9 in controlling peritoneal immune cell recruitment and FALC formation at baseline and after sepsis induced by cecal ligation and puncture (CLP).
|
31380807 |
2019 |
Septicemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The activation of the TLR4/TLR9/p38 MAPK/STAT3 signal pathway contributes to the production of miR-23b in CLP-induced sepsis. miR-23b inhibitor decreased the number of spleen cells positive by terminal deoxynucleotidyl transferase dUTP nick-end labeling and improved survival. miR-23b inhibitor restored the immunoreactivity by alleviating the development of T-cell exhaustion and producing smaller amounts of immunosuppressive interleukin 10 and interleukin 4 during late sepsis.
|
29506272 |
2018 |
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Harmful Roles of TLR3 and TLR9 in Cardiac Dysfunction Developing during Polymicrobial Sepsis.
|
30364002 |
2018 |
Septicemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
There is no relation between sepsis and both TLR-9 (C>T) and TLR-9(-1486 T>C) polymorphisms; however, there is a relation between sepsis and decreased serum TLR-9 levels of both TLR-9 (-1486 T>C) TT and TLR-9 (C>T) TT polymorphisms due to sepsis-associated immunosuppression.
|
27566084 |
2017 |
Septicemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Cell-free DNA from all three sources may play a pathogenic role in sepsis via activation of coagulation through the contact pathway, whereas CpG motifs on bacterial and mitochondrial DNA may additionally stimulate inflammatory responses via Toll-like receptor 9.
|
25944792 |
2015 |
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to investigate the associations between expression of TLR2, TLR4 and TLR9 and occurrence of sepsis in patients treated with intensive induction chemotherapy for AML.
|
25412934 |
2014 |
Septicemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We found that mice developed AKI in our model of polymicrobial sepsis, despite fluid and antibiotic resuscitation, which resembles human sepsis. siRNA to TLR9 successfully silenced the induction of renal TLR9 gene and protein expression following CLP.
|
23548820 |
2012 |
Septicemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
TLR9 polymorphisms rs187084 and rs352162 might be used to provide relevant risk estimates for the development of sepsis and MOD in patients with major trauma.
|
21633947 |
2011 |
Septicemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Compared with patients with TC/TT gene at position 1486 of TLR9, patients with the homozygous CC gene variant had a lower TLR9 mRNA expression and a delayed T-cell immune reconstitution after transplant, which might prevent them from overwhelming immune responses as sepsis or systemic inflammatory response syndrome (SIRS) associated with an increased TRM.
|
19252531 |
2009 |