|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Toll-like receptor 9 (TLR9) plays a crucial role in the innate immune response against viral infections.
|
30453064 |
2019 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
A unique nanoparticulate TLR9 agonist enables a HA split vaccine to confer FcγR-mediated protection against heterologous lethal influenza virus infection.
|
30535055 |
2019 |
|
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In contrast, oncogenic DNA viruses like hepatitis B virus, Epstein-Barr virus, and human papilloma virus inhibit TLR9 expression, thus contributing to the establishment of chronic viral infections.
|
28151089 |
2017 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Plasmacytoid dendritic cells (pDCs) are a unique subset of naturally occurring dendritic cells, which triggers the production of large amounts of type I interferons (IFNs) after viral infections through Toll-like receptor (TLR) 7 and TLR9.
|
28052019 |
2017 |
|
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Importantly, we present evidence that the HPV16-induced TLR9 down-regulation affects the interferon response which negatively regulates viral infection.
|
23752229 |
2013 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
By using small interfering RNA screening, we further demonstrated that, among the RIG-I-like receptors (RLRs) and Toll-like receptors (TLRs), only TLR2, TLR6, TLR7, and TLR9 contribute to the NF-κB-dependent secretion of TNF and the inflammasome-dependent secretion of IL-1β in response to vMyxM013-KO virus infection.
|
21957307 |
2011 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Among TLRs, TLR9 recognizes unmethylated 2'-deoxyribo (cytidine-phosphate guanosine)(CpG) DNA motifs that are frequently present in viruses and plays a central role in the host defense against viral infection.
|
21595536 |
2011 |
|
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In the BioBreeding Diabetes Resistant (BBDR) rat, however, diabetes induced by virus infection involves the upregulation of TLR9 pathways, and generic TLR upregulation synergizes with virus infection on diabetes induction.
|
19199942 |
2009 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
These experiments of nature suggest that the TLR7-, TLR8-, and TLR9-dependent induction of IFN-alpha, IFN-beta, and IFN-lambda is largely redundant in human antiviral immunity, whereas the TLR3-dependent induction of IFN-alpha, IFN-beta, and IFN-lambda is critical for primary immunity to HSV-1 in the central nervous system in children but redundant for immunity to most other viral infections.
|
17979850 |
2007 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Lack of functioning Btk in XLA patients downstream of TLR8 and TLR9 might explain the susceptibility of XLA patients to viral infections.
|
17932028 |
2007 |
|
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Plasmacytoid dendritic cells, activated by bacterial antigens via TLR9 or by viral infection, did not produce the protein.
|
14688085 |
2004 |