For TLR9-1486, an association between the CT + TT genotypes and increased risk of both GC (dominant model OR = 2.72, 95%CI: 1.57-4.72, <i>P</i> < 0.0001) and CG (dominant model OR = 1.79, 95%CI: 1.15-2.79, <i>P</i> = 0.0094) was observed when compared to the C group.
In conclusion, our study suggests that alterations of flaA protein, moderate motility in <i>H. pylori</i> and two polymorphisms in TLR5 and TLR9 may favor the onset of AAG and GC, at least in a subset of patients.
The aim of this study was to determine whether the polymorphisms of TLR4 and TLR9 are associated with susceptibility to gastric carcinoma and its prognosis.
The genomic DNA of toll-like receptor (TLR) 2, TLR4, radioprotective 105, TLR6, and TLR9 were examined for mutations in 48 patients with gastric cancer.