GPR88, G protein-coupled receptor 88, 54112

N. diseases: 21; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4310787
Disease: CHOREA, CHILDHOOD-ONSET, WITH PSYCHOMOTOR RETARDATION
CHOREA, CHILDHOOD-ONSET, WITH PSYCHOMOTOR RETARDATION 		0.400 CausalMutation disease CLINVAR
CUI: C4310787
Disease: CHOREA, CHILDHOOD-ONSET, WITH PSYCHOMOTOR RETARDATION
CHOREA, CHILDHOOD-ONSET, WITH PSYCHOMOTOR RETARDATION 		0.400 Biomarker disease CTD_human
CUI: C0008489
Disease: Chorea
Chorea 		0.100 Biomarker phenotype HPO
CUI: C0476217
Disease: Head movements abnormal
Head movements abnormal 		0.100 Biomarker phenotype HPO
CUI: C0557874
Disease: Global developmental delay
Global developmental delay 		0.100 Biomarker disease HPO
CUI: C1848207
Disease: Poor speech
Poor speech 		0.100 Biomarker phenotype HPO
CUI: C3714756
Disease: Intellectual Disability
Intellectual Disability 		0.100 Biomarker group HPO
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.030 AlteredExpression disease BEFREE GPR88, a brain-specific oGPCR with particularly robust expression in the striatum, regulates diverse brain and behavioral functions, including cognition, mood, movement control, and reward-based learning, and is thus emerging as a novel drug target for central nervous system disorders including schizophrenia, Parkinson's disease, anxiety, and addiction. 30540906 2019
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.030 Biomarker disease BEFREE Knockout (KO) mice lacking GPR88 throughout the brain exhibit many abnormalities relevant to schizophrenia including locomotor hyperactivity, behavioural hypersensitivity to dopaminergic psychostimulants and deficient sensorimotor gating. 28700108 2017
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.030 AlteredExpression disease BEFREE In rodents, the orphan G protein-coupled receptor, Gpr88, is highly expressed in brain regions implicated in the pathophysiology of and is modulated by treatments for schizophrenia. 19796684 2009
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.020 Biomarker disease BEFREE Intact male GPR88 KO mice showed diminished tacrine-induced PD-like tremor and spontaneous hyperlocomotion. 31666199 2020
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.020 AlteredExpression disease BEFREE GPR88, a brain-specific oGPCR with particularly robust expression in the striatum, regulates diverse brain and behavioral functions, including cognition, mood, movement control, and reward-based learning, and is thus emerging as a novel drug target for central nervous system disorders including schizophrenia, Parkinson's disease, anxiety, and addiction. 30540906 2019
CUI: C0424295
Disease: Hyperactive behavior
Hyperactive behavior 		0.020 Biomarker phenotype BEFREE The orphan G protein-coupled receptor GPR88 is enriched in mesocorticolimbic pathways, and Gpr88 knockout mice show hyperactivity and risk-taking behavior, but a potential role for this receptor in drug abuse has not been examined. 29580570 2018
CUI: C0424295
Disease: Hyperactive behavior
Hyperactive behavior 		0.020 Biomarker phenotype BEFREE Knockout (KO) mice lacking GPR88 throughout the brain exhibit many abnormalities relevant to schizophrenia including locomotor hyperactivity, behavioural hypersensitivity to dopaminergic psychostimulants and deficient sensorimotor gating. 28700108 2017
CUI: C0013384
Disease: Dyskinetic syndrome
Dyskinetic syndrome 		0.010 GeneticVariation disease BEFREE Genetic deletion of GPR88 enhances the locomotor response to L-DOPA in experimental parkinsonism while counteracting the induction of dyskinesia. 31666199 2020
CUI: C0040822
Disease: Tremor
Tremor 		0.010 Biomarker phenotype BEFREE Intact male GPR88 KO mice showed diminished tacrine-induced PD-like tremor and spontaneous hyperlocomotion. 31666199 2020
CUI: C0242422
Disease: Parkinsonian Disorders
Parkinsonian Disorders 		0.010 Biomarker group BEFREE Here, we studied the role of GPR88 in experimental parkinsonism and LID. 31666199 2020
CUI: C0392702
Disease: Abnormal involuntary movement
Abnormal involuntary movement 		0.010 Biomarker disease BEFREE Conversely, GPR88 KO mice had a lower abnormal involuntary movements (AIMs) score. 31666199 2020
CUI: C0007682
Disease: CNS disorder
CNS disorder 		0.010 AlteredExpression group BEFREE GPR88, a brain-specific oGPCR with particularly robust expression in the striatum, regulates diverse brain and behavioral functions, including cognition, mood, movement control, and reward-based learning, and is thus emerging as a novel drug target for central nervous system disorders including schizophrenia, Parkinson's disease, anxiety, and addiction. 30540906 2019
CUI: C0085281
Disease: Addictive Behavior
Addictive Behavior 		0.010 AlteredExpression phenotype BEFREE GPR88, a brain-specific oGPCR with particularly robust expression in the striatum, regulates diverse brain and behavioral functions, including cognition, mood, movement control, and reward-based learning, and is thus emerging as a novel drug target for central nervous system disorders including schizophrenia, Parkinson's disease, anxiety, and addiction. 30540906 2019
CUI: C0013146
Disease: Drug abuse
Drug abuse 		0.010 Biomarker group BEFREE The orphan G protein-coupled receptor GPR88 is enriched in mesocorticolimbic pathways, and Gpr88 knockout mice show hyperactivity and risk-taking behavior, but a potential role for this receptor in drug abuse has not been examined. 29580570 2018
CUI: C0013170
Disease: Drug habituation
Drug habituation 		0.010 Biomarker phenotype BEFREE In the free adaptation phase, Gpr88 <sup>-/-</sup> mice showed delayed habituation to the home cage, and increased frequency of same corner returns behavior in their alternation pattern. 29575471 2018
CUI: C0003123
Disease: Anorexia
Anorexia 		0.010 Biomarker disease BEFREE In addition, GPR88 deficiency was associated with altered expressions of the anorectic Pomc and the orexigenic Npy in the arcuate nucleus, especially under HFD condition. 28855710 2017
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.010 Biomarker group BEFREE Therefore, we conclude that GPR88 and GPR124 receptors may be involved in the development or maintenance of high blood pressure. 28678544 2017
CUI: C0004936
Disease: Mental disorders
Mental disorders 		0.010 Biomarker group BEFREE The modulatory role of Gpr88 in striatal dopamine function suggests it may be a new target for treatments for psychiatric disorders. 19796684 2009