Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.010 Biomarker disease BEFREE Overall, our results identify TREM2 as a potential prognostic biomarker and therapeutic target for colorectal cancer. 31489935 2019
CUI: C0014544
Disease: Epilepsy
Epilepsy 		0.010 Biomarker disease BEFREE Trem2 was found to occupy a core position and was correlated with epilepsy. 30684126 2019
CUI: C0020443
Disease: Hypercholesterolemia
Hypercholesterolemia 		0.010 Biomarker disease BEFREE Genetic ablation of Trem2 in mice globally inhibits the downstream molecular LAM program, leading to adipocyte hypertrophy as well as systemic hypercholesterolemia, body fat accumulation, and glucose intolerance. 31257031 2019
CUI: C0025517
Disease: Metabolic Diseases
Metabolic Diseases 		0.010 AlteredExpression group BEFREE These findings identify Trem2 signaling as a major pathway by which macrophages respond to loss of tissue-level lipid homeostasis, highlighting Trem2 as a key sensor of metabolic pathologies across multiple tissues and a potential therapeutic target in metabolic diseases. 31257031 2019
CUI: C0262405
Disease: Cerebral dysfunction
Cerebral dysfunction 		0.010 Biomarker disease BEFREE Although loss of TREM2 and progranulin resulted in opposite activation states and functional phenotypes of microglia, FDG (fluoro-2-deoxy-d-glucose)-μPET of brain revealed reduced glucose metabolism in both conditions, suggesting that opposite microglial phenotypes result in similar wide spread brain dysfunction. 31122931 2019
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.010 Biomarker phenotype BEFREE Genetic ablation of Trem2 in mice globally inhibits the downstream molecular LAM program, leading to adipocyte hypertrophy as well as systemic hypercholesterolemia, body fat accumulation, and glucose intolerance. 31257031 2019
CUI: C0282513
Disease: Primary Progressive Aphasia (disorder)
Primary Progressive Aphasia (disorder) 		0.010 GeneticVariation disease BEFREE Rare risk variants, TREM2 R47H and MAPT A152T, were associated with a three- to seven-fold increase in risk for PPA. 30599136 2019
CUI: C0424295
Disease: Hyperactive behavior
Hyperactive behavior 		0.010 Biomarker phenotype BEFREE Interestingly, after LPS treatment, TLR4 expression was persistently up-regulated, while TREM2 expression was significantly down-regulated in APP/PS1 mice, suggesting that the negative regulatory effect of TREM2 on inflammation might be suppressed by LPS-induced hyperactive TLR4. 30756214 2019
CUI: C3266262
Disease: Multiple Chronic Conditions
Multiple Chronic Conditions 		0.010 Biomarker disease BEFREE TYROBP/DAP12 forms complexes with ectodomains of immune receptors (TREM2, SIRPβ1, CR3) associated with Alzheimer's disease (AD) and is a network hub and driver in the complement subnetwork identified by multi-scale gene network studies of postmortem human AD brain. 30283031 2019
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.010 Biomarker disease BEFREE Overall, our results identify TREM2 as a potential prognostic biomarker and therapeutic target for colorectal cancer. 31489935 2019
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.010 AlteredExpression disease BEFREE TREM2 protein levels were also negatively correlated with the severity of symptoms in humans affected by autism. 29752066 2018
CUI: C0007282
Disease: Carotid Stenosis
Carotid Stenosis 		0.010 AlteredExpression disease BEFREE TREM2 levels have been observed to affect plasma levels of TNF-α and plaque stability in symptomatic and asymptomatic patients with carotid stenosis. 29740051 2018
CUI: C0007785
Disease: Cerebral Infarction
Cerebral Infarction 		0.010 Biomarker disease BEFREE Altogether, the results show that TREM2 could be a potential target in EA treatment for attenuating inflammatory injury following cerebral ischemia/reperfusion. 30149915 2018
CUI: C0011854
Disease: Diabetes Mellitus, Insulin-Dependent
Diabetes Mellitus, Insulin-Dependent 		0.010 Biomarker disease BEFREE Downregulating TREM2 and total NF-κB p65 and inhibiting NF-κB p65 nucleus translocation were also confirmed in NP tissue samples of four IDD rats. 30076618 2018
CUI: C0022568
Disease: Keratitis
Keratitis 		0.010 Biomarker disease BEFREE Our study demonstrated that TREM2 promotes host resistance against <i>P. aeruginosa</i> keratitis by inhibiting caspase-1-dependent pyroptosis, which provides new insights of TREM2-mediated anti-bacterial immunity. 29887864 2018
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.010 AlteredExpression disease BEFREE TREM2 mRNA and protein expression levels were both significantly higher in GC compared with normal gastric tissues (P<.0001 and P<.001, respectively). 29104108 2018
CUI: C0025202
Disease: melanoma
melanoma 		0.010 AlteredExpression disease BEFREE TREM2 was also activated by A + N in U-2 OS osteosarcoma and A375 melanoma cell lines. 29842899 2018
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.010 AlteredExpression disease BEFREE TREM2 was also activated by A + N in U-2 OS osteosarcoma and A375 melanoma cell lines. 29842899 2018
CUI: C0031117
Disease: Peripheral Neuropathy
Peripheral Neuropathy 		0.010 Biomarker group BEFREE Functional blockage of TREM2 or inhibition of microglia both benefited for cisplatin-induced peripheral neuropathy. 29051087 2018
CUI: C0042373
Disease: Vascular Diseases
Vascular Diseases 		0.010 Biomarker group BEFREE We reveal an unexpected potential role of Trem2 in the homeostasis of endothelial cells that goes beyond its known functions as a microglial receptor and signaling hub, suggesting an underlying link between immune response and vascular disease in dementia. 29906661 2018
CUI: C0158252
Disease: Intervertebral disc disorder
Intervertebral disc disorder 		0.010 Biomarker group BEFREE Downregulating TREM2 and total NF-κB p65 and inhibiting NF-κB p65 nucleus translocation were also confirmed in NP tissue samples of four IDD rats. 30076618 2018
CUI: C0270612
Disease: Leukoencephalopathy
Leukoencephalopathy 		0.010 GeneticVariation group BEFREE Loss-of-function mutations in TREM2 cause Nasu-Hakola disease (NHD), a rare genetic disease characterized by early-onset dementia with leukoencephalopathy and bone cysts. 29720600 2018
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone 		0.010 AlteredExpression disease BEFREE TREM2 was also activated by A + N in U-2 OS osteosarcoma and A375 melanoma cell lines. 29842899 2018
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.010 AlteredExpression disease BEFREE TREM2 mRNA and protein expression levels were both significantly higher in GC compared with normal gastric tissues (P<.0001 and P<.001, respectively). 29104108 2018
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma 		0.010 AlteredExpression disease BEFREE TREM2 was also activated by A + N in U-2 OS osteosarcoma and A375 melanoma cell lines. 29842899 2018