Several risk genes, such as Apolipoprotein E4 and TREM-2 enhance the risk of sporadic AD, but also many risk factors associated with life style (e.g., diabetes, hypercholesterolemia, stress) may play a role.
mRNA transcripts and protein expression of TREM-1, TREM-2, and TREM-1/TREM-2 ratio were examined in the tissue biopsies (liver, omentum, and subcutaneous fat) and blood samples (neutrophils and monocytes) of subjects with obesity and diabetes (SO<sup>+</sup> D<sup>+</sup> ; n = 15), subjects with obesity but not diabetes (SO<sup>+</sup> D<sup>-</sup> ; n = 7), and subjects without obesity (BMI < 30) and diabetes (SO<sup>-</sup> D<sup>-</sup> ; n = 5).