POLH, DNA polymerase eta, 5429

N. diseases: 44; N. variants: 18
Disease: Skin Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0037286
Disease: Skin Neoplasms
Skin Neoplasms 		0.020 Biomarker group BEFREE Both Chk2<sup>-/-</sup> and Chk2<sup>-/-</sup>Rad18<sup>-/-</sup> mice were prone to UV-B irradiation-induced skin tumorigenesis when compared with wild-type (WT) animals, but unexpectedly Rad18<sup>-/-</sup> mice did not recapitulate the skin tumor propensity of Polη mutants. 29859927 2018
CUI: C0037286
Disease: Skin Neoplasms
Skin Neoplasms 		0.020 AlteredExpression group BEFREE As determined by RT-PCR, POLH mRNA was expressed in all normal and skin tumour tissue examined. 17334634 2007