|
Autism Spectrum Disorders
|
0.600 |
Biomarker
|
disease |
BEFREE |
Here, we describe a synaptic cluster of ASD-associated proteins centered on CYFIP1 and the adhesion protein Neuroligin-3.
|
30664619 |
2019 |
|
Autism Spectrum Disorders
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our report of two missense variants affecting the normal localization of NLGN3 in a total of five affected individuals reinforces the involvement of the NLGN3 gene in a neurodevelopmental disorder characterized by ID and ASD.
|
31184401 |
2019 |
|
Autism Spectrum Disorders
|
0.600 |
Biomarker
|
disease |
BEFREE |
Among these genes are FMR1, CYFIP1 and NLGN3, all present at the synapse and reliably linked to ASD.
|
31705895 |
2019 |
|
Autism Spectrum Disorders
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Here, we examined how mutations in the synaptic cell-adhesion molecule neuroligin-3 (Nlgn3) that have been documented in ASD impact relational memory and behavioral flexibility.
|
31827744 |
2019 |
|
Autism Spectrum Disorders
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The neurobiological bases of autism spectrum disorders: the R451C-neuroligin 3 mutation hampers the expression of long-term synaptic depression in the dorsal striatum.
|
28921757 |
2018 |
|
Autism Spectrum Disorders
|
0.600 |
Biomarker
|
disease |
BEFREE |
Global or VTA DA neuron-specific loss of the ASD-associated synaptic adhesion molecule neuroligin 3 alters the behavioral response toward nonfamiliar conspecifics and the reinforcing properties of conspecific interaction.
|
30093665 |
2018 |
|
Autism Spectrum Disorders
|
0.600 |
Biomarker
|
disease |
BEFREE |
The Neuroligin-3 (NL3)<sup>R451C</sup> mouse model of ASD has a heightened aggressive phenotype, however the biological mechanisms underlying this behavior are unknown.
|
30123111 |
2018 |
|
Autism Spectrum Disorders
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Our results directly link Wnt/β-catenin signaling to the transcription of the Nlgn3 gene and support a functional role for the signaling pathway in the dysregulation of excitatory/inhibitory neuronal activity, as is observed in animal models of ASD.
|
29503438 |
2018 |
|
Autism Spectrum Disorders
|
0.600 |
Biomarker
|
disease |
BEFREE |
Since neuroligin3 (NLGN3), a cell adhesion molecule at the neuronal synapse, was first identified as a risk gene for ASD, several additional variants in NLGN3 and NLGN4 were found in ASD patients.
|
28841651 |
2017 |
|
Autism Spectrum Disorders
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The Neuroligin-3 (NL3) mouse, expressing a R451C mutation discovered in two Swedish brothers with ASD, exhibits impaired social interactions and heightened aggressive behavior towards male mice.
|
28255463 |
2017 |
|
Autism Spectrum Disorders
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Neuroligin 3 R451C mutation alters electroencephalography spectral activity in an animal model of autism spectrum disorders.
|
28385162 |
2017 |
|
Autism Spectrum Disorders
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The sleep disruptions in Nlgn3 KO rats are consistent with observations of sleep disturbances in ASD patients.
|
28958035 |
2017 |
|
Autism Spectrum Disorders
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Knock-in mice carrying a single rare point mutation of NLGN3 (NLGN3 R451C) discovered in the patients with ASDs display a deficit in social interaction and an enhancement of spatial learning and memory ability reminiscent of the clinical phenotype of ASDs.
|
27743928 |
2017 |
|
Autism Spectrum Disorders
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In the face of growing controversy about the utility of genetic mouse models of human disease, Rothwell et al. report on a shared mechanism by which two different neuroligin-3 mutations, associated with autism spectrum disorders in humans, produce an enhancement in motor learning.
|
24995974 |
2014 |
|
Autism Spectrum Disorders
|
0.600 |
Biomarker
|
disease |
RGD |
FMRP, a protein with numerous proposed functions including regulation of mRNA and synaptic protein synthesis, and NLGN3, a member of the neuroligin synaptic cell-adhesion protein family, have been implicated in human ASD.
|
24773431 |
2014 |
|
Autism Spectrum Disorders
|
0.600 |
Biomarker
|
disease |
BEFREE |
Neuroligin-3 (NL-3) is a cell adhesion protein that mediates synapse development and has been implicated in ASD.
|
25299583 |
2014 |
|
Autism Spectrum Disorders
|
0.600 |
Biomarker
|
disease |
BEFREE |
It has been shown that many genes associated with ASDs are involved in the neuroligin-neurexin interaction at the glutamate synapse: NLGN3, NLGN4, NRXN1, CNTNAP2, and SHANK3.
|
22892527 |
2013 |
|
Autism Spectrum Disorders
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The present study provides initial evidence that a common variant in NLGN3 gene may play a role in the etiology of ASDs among affected males in Chinese Han population, and further supports the hypothesis that defect of synapse might involvement in the pathophysiology of ASDs.
|
21569590 |
2011 |
|
Autism Spectrum Disorders
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Both mutated CADM1 and neuroligin 3(R451C) induced upregulation of C/EBP-homologous protein (CHOP), an ER stress marker, suggesting that in addition to the trafficking impairment, this CHOP upregulation may also be involved in ASD pathogenesis.
|
21364653 |
2010 |
|
Autism Spectrum Disorders
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We conclude that there is no evidence for an involvement of NLGN3 and NLGN4X genetic variants with autism spectrum disorder on high functioning level in our study group.
|
18189281 |
2008 |
|
Autism Spectrum Disorders
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Recent studies reported that sequence polymorphisms in neuroligin-3 (NLGN3) and neuroligin-4 (NLGN4) genes have been linked to autism spectrum disorders indicating neuroligin genes as candidate targets in brain disorders.
|
18555979 |
2008 |
|
Autism Spectrum Disorders
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Neuroligin abnormalities have been recently implicated in the aetiology of autism spectrum disorders (ASD), given the finding of point mutations in the two X-linked genes NLGN3 and NLGN4X and the important role of neuroligins in synaptogenesis.
|
16508939 |
2006 |
|
Autism Spectrum Disorders
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Family-based association analysis in 100 families with autism spectrum disorders yielded only modest associations at NLGN1 (rs1488545, P=0.002), NLGN3 (DXS7132, P=0.014), and NLGN4 (DXS996, P=0.031).
|
16077734 |
2005 |
|
Autism Spectrum Disorders
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A recent study reported that a mutation of neuroligin-3 (NL3), an X-linked gene, was found in siblings with autistic spectrum disorder in which two affected brothers had a point mutation that substituted a Cys for Arg451.
|
15152050 |
2004 |
|
Autism Spectrum Disorders
|
0.600 |
Biomarker
|
disease |
BEFREE |
Here we report mutations in two X-linked genes encoding neuroligins NLGN3 and NLGN4 in siblings with autism-spectrum disorders.
|
12669065 |
2003 |