|
Endometrioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this paper we studied whether ovarian cortex adjacent to excised small (diameter ≤ 4 cm) endometriotic cyst (here referred as Cortex Surrounding Endometriotic Cyst, CSEC) showed signs of tissue damages by evaluating the expression of proteins involved in DNA repair and apoptosis.
|
31416694 |
2019 |
|
Sleeplessness
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Symptoms of depression confirmed with depression inventory≥ 10 occurred as follows: patients with rheumatoid arthritis - 75.83%, patients with osteoarthritis - 50%, control group - 23.53% (p<0.0001), with the prevalence of insomnia (AIS≥6) at: 71%, 32% and 33%, respectively (p<0.001).
|
30286609 |
2019 |
|
Diabetes
|
0.010 |
Biomarker
|
disease |
BEFREE |
Technology-facilitated care was significantly associated with depression remission (technology-facilitated care vs usual care: OR=2.98, P=.04); increased satisfaction with care for emotional problems among depressed patients (LSE: usual care=3.20, technology-facilitated care=3.70; P=.05); reduced total cholesterol level (LSE: usual care=176.40, technology-facilitated care=160.46; P=.01); improved satisfaction with diabetes care (LSE: usual care=4.01, technology-facilitated care=4.20; P=.05); and increased odds of taking an glycated hemoglobin test (technology-facilitated care vs usual care: OR=3.40, P<.001).
|
29685872 |
2018 |
|
Diabetes Mellitus
|
0.010 |
Biomarker
|
group |
BEFREE |
Technology-facilitated care was significantly associated with depression remission (technology-facilitated care vs usual care: OR=2.98, P=.04); increased satisfaction with care for emotional problems among depressed patients (LSE: usual care=3.20, technology-facilitated care=3.70; P=.05); reduced total cholesterol level (LSE: usual care=176.40, technology-facilitated care=160.46; P=.01); improved satisfaction with diabetes care (LSE: usual care=4.01, technology-facilitated care=4.20; P=.05); and increased odds of taking an glycated hemoglobin test (technology-facilitated care vs usual care: OR=3.40, P<.001).
|
29685872 |
2018 |
|
Drug abuse
|
0.010 |
Biomarker
|
group |
BEFREE |
Average (SD) age was 15.4 (1.8) years for CSEC/CST patients and 14.8 (1.6) years for ASA patients; 100% of the CSEC/CST and 95% of the ASA patients were female.
|
26599463 |
2018 |
|
Retinopathy of Prematurity
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
LncRNA of POLDIP2, GAS5, NEFL and UHRF1, circRNA of ZNF280C_hsa_circ_001211 and SIAE_hsa_circ_002083, tar-get gene of QKI showed meaningful differential expression in ROP.
|
29862174 |
2018 |
|
Unipolar Depression
|
0.010 |
Biomarker
|
disease |
BEFREE |
Compared with usual care, both the supported care and technology-facilitated care groups were associated with significant reduction in depressive symptoms measured by scores on the 9-item Patient Health Questionnaire (least squares estimate, LSE: usual care=6.35, supported care=5.05, technology-facilitated care=5.16; P value: supported care vs usual care=.02, technology-facilitated care vs usual care=.02); decreased prevalence of major depression (odds ratio, OR: supported care vs usual care=0.45, technology-facilitated care vs usual care=0.33; P value: supported care vs usual care=.02, technology-facilitated care vs usual care=.007); and reduced functional disability as measured by Sheehan Disability Scale scores (LSE: usual care=3.21, supported care=2.61, technology-facilitated care=2.59; P value: supported care vs usual care=.04, technology-facilitated care vs usual care=.03).
|
29685872 |
2018 |
|
Major Depressive Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Compared with usual care, both the supported care and technology-facilitated care groups were associated with significant reduction in depressive symptoms measured by scores on the 9-item Patient Health Questionnaire (least squares estimate, LSE: usual care=6.35, supported care=5.05, technology-facilitated care=5.16; P value: supported care vs usual care=.02, technology-facilitated care vs usual care=.02); decreased prevalence of major depression (odds ratio, OR: supported care vs usual care=0.45, technology-facilitated care vs usual care=0.33; P value: supported care vs usual care=.02, technology-facilitated care vs usual care=.007); and reduced functional disability as measured by Sheehan Disability Scale scores (LSE: usual care=3.21, supported care=2.61, technology-facilitated care=2.59; P value: supported care vs usual care=.04, technology-facilitated care vs usual care=.03).
|
29685872 |
2018 |
|
Sleep disturbances
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
All patients had consistent sleep disturbances (AIS ≥6), with a large number of patients having intense-maximum sleep disturbances.
|
27957622 |
2017 |
|
Psychiatric symptom
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Low (LSE, n=40) and high (HSE, n=45) self-esteem participants were assessed in their interpersonal problems and psychiatric symptoms using self-reported questionnaires, and were compared on their decision making and emotional response during the UG.
|
28285253 |
2017 |
|
Sleep Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
All patients had consistent sleep disturbances (AIS ≥6), with a large number of patients having intense-maximum sleep disturbances.
|
27957622 |
2017 |
|
Anxiety symptoms
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
LSE was associated with depression and anxiety symptoms.
|
28285253 |
2017 |
|
[D]Sleep disturbances (& [hypersomnia] or [insomnia])
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
All patients had consistent sleep disturbances (AIS ≥6), with a large number of patients having intense-maximum sleep disturbances.
|
27957622 |
2017 |
|
Juvenile arthritis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Considering the distinct pathogenesis of the two main subtypes of JIA, autoinflammatory systemic (sJIA) and autoimmune oligo/polyarticular (aJIA), and a predisposition to autoimmunity displayed by patients and families with primary antibody deficiencies (PADs), the aim of our study was to analyze whether <i>SIAE</i> rare variants are associated with both the phenotype of JIA and the autoimmunity risk in families with PADs.
|
28900629 |
2017 |
|
Rheumatoid Arthritis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
No significant differences in the seven SNPs of SIAE were observed between patients with RA and controls in this cohort (P > 0.05).
|
26535733 |
2015 |
|
Anti-PIT-1 Antibody Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Considering the physiological function of SIAE and the clinical features of anti-PIT-1 antibody syndrome, present data imply a novel aspect of the pathogenesis in this disease.
|
24748456 |
2014 |
|
Primary biliary cirrhosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Sequencing of the SIAE gene and functional assays of newly identified variants revealed six patients with functional non-synonymous SIAE mutations (Fisher's P=9 × 10(-4) vs controls) We demonstrate independent effects on risk of PBC for CLEC16A, SOCS1 and SPIB variants, while identifying functionally defective SIAE variants as potential factors in risk for PBC.
|
22257840 |
2012 |
|
Childhood Acute Lymphoblastic Leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
These studies demonstrate that both SIAE and SOAT activities seem to be responsible for the enhanced level of Neu5,9Ac(2) in lymphoblasts, which is a hallmark in ALL.
|
21803834 |
2012 |
|
Addison's disease due to autoimmunity
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We demonstrated the presence of 89*V homozygotes and the 312*M rare allele in the AAD cohort, but overall, our analysis does not support a role for rare variants in SIAE in the pathogenesis of AAD.
|
23011869 |
2012 |
|
Autoimmune Primary Adrenal Insufficiency
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We demonstrated the presence of 89*V homozygotes and the 312*M rare allele in the AAD cohort, but overall, our analysis does not support a role for rare variants in SIAE in the pathogenesis of AAD.
|
23011869 |
2012 |
|
Graves Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Functionally defective germline variant of sialic acid acetylesterase (Met89Val) is not associated with type 1 diabetes mellitus and Graves' disease in a Polish population.
|
21615338 |
2011 |