|
AUTOIMMUNE DISEASE, SUSCEPTIBILITY TO, 6
|
0.400 |
GeneticVariation
|
disease |
UNIPROT |
Functionally defective germline variants of sialic acid acetylesterase in autoimmunity.
|
20555325 |
2010 |
|
AUTOIMMUNE DISEASE, SUSCEPTIBILITY TO, 6
|
0.400 |
SusceptibilityMutation
|
disease |
CLINVAR |
|
|
|
|
Autoimmune Diseases
|
0.370 |
GeneticVariation
|
group |
BEFREE |
Our results show that <i>SIAE</i> rare variants are not causative of autoimmunity as single defects.
|
28900629 |
2017 |
|
Autoimmune Diseases
|
0.370 |
Biomarker
|
group |
BEFREE |
Sialic acid acetylesterase (SIAE) removes acetyl moieties from the carbon 9 and 4 hydroxyl groups of sialic acid and recently a debate has been opened on its association to autoimmunity.
|
28922741 |
2017 |
|
Autoimmune Diseases
|
0.370 |
GeneticVariation
|
group |
BEFREE |
The function of rare genotypes encoding defective variants of sialic acid acetylesterase (SIAE) in some autoimmune diseases, including rheumatoid arthritis (RA), is ambiguous.
|
26535733 |
2015 |
|
Autoimmune Diseases
|
0.370 |
Biomarker
|
group |
BEFREE |
Sialic acid acetylesterase (SIAE) plays a crucial role in regulating the threshold of autoantibody production of B-cells and the defective variants of SIAE are associated with an increased risk of various autoimmune diseases such as type 1 diabetes (T1DM).
|
24748456 |
2014 |
|
Autoimmune Diseases
|
0.370 |
GeneticVariation
|
group |
BEFREE |
We fine mapped two primary biliary cirrhosis (PBC) risk loci, CLEC16A (C-type lectin domain family 16 member A)-suppressor of cytokine signaling 1 (SOCS1) and Spi-B protein (SPIB) and sequenced a locus, sialic acid acetylesterase (SIAE), proposed to harbor autoimmunity-associated mutations.
|
22257840 |
2012 |
|
Autoimmune Diseases
|
0.370 |
GeneticVariation
|
group |
BEFREE |
We conclude that further studies are needed before the proposed strong effect of defective SIAE variants on susceptibility to autoimmunity can be universally accepted.
|
21615338 |
2011 |
|
Autoimmune Diseases
|
0.370 |
GeneticVariation
|
group |
BEFREE |
Functionally defective SIAE rare and polymorphic variants represent a strong genetic link to susceptibility in relatively common human autoimmune disorders.
|
20555325 |
2010 |
|
Autoimmune Diseases
|
0.370 |
Biomarker
|
group |
CTD_human |
|
|
|
|
Serum albumin measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Genetic determinants influencing human serum metabolome among African Americans.
|
24625756 |
2014 |
|
Mental Depression
|
0.030 |
Biomarker
|
disease |
BEFREE |
In all subjects with AIS≥6, the depression inventory was statistically significantly (p<0.005) higher than in the subjects with AIS<6 (respectively: 17.02 vs 12.13; 15.6 vs 8.05; 5.45 vs 1.81).
|
30286609 |
2019 |
|
Depressive disorder
|
0.030 |
Biomarker
|
disease |
BEFREE |
In all subjects with AIS≥6, the depression inventory was statistically significantly (p<0.005) higher than in the subjects with AIS<6 (respectively: 17.02 vs 12.13; 15.6 vs 8.05; 5.45 vs 1.81).
|
30286609 |
2019 |
|
Depressed mood
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
In all subjects with AIS≥6, the depression inventory was statistically significantly (p<0.005) higher than in the subjects with AIS<6 (respectively: 17.02 vs 12.13; 15.6 vs 8.05; 5.45 vs 1.81).
|
30286609 |
2019 |
|
Mental Depression
|
0.030 |
Biomarker
|
disease |
BEFREE |
Technology-facilitated care was significantly associated with depression remission (technology-facilitated care vs usual care: OR=2.98, P=.04); increased satisfaction with care for emotional problems among depressed patients (LSE: usual care=3.20, technology-facilitated care=3.70; P=.05); reduced total cholesterol level (LSE: usual care=176.40, technology-facilitated care=160.46; P=.01); improved satisfaction with diabetes care (LSE: usual care=4.01, technology-facilitated care=4.20; P=.05); and increased odds of taking an glycated hemoglobin test (technology-facilitated care vs usual care: OR=3.40, P<.001).
|
29685872 |
2018 |
|
Depressive disorder
|
0.030 |
Biomarker
|
disease |
BEFREE |
Technology-facilitated care was significantly associated with depression remission (technology-facilitated care vs usual care: OR=2.98, P=.04); increased satisfaction with care for emotional problems among depressed patients (LSE: usual care=3.20, technology-facilitated care=3.70; P=.05); reduced total cholesterol level (LSE: usual care=176.40, technology-facilitated care=160.46; P=.01); improved satisfaction with diabetes care (LSE: usual care=4.01, technology-facilitated care=4.20; P=.05); and increased odds of taking an glycated hemoglobin test (technology-facilitated care vs usual care: OR=3.40, P<.001).
|
29685872 |
2018 |
|
Depressed mood
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Technology-facilitated care was significantly associated with depression remission (technology-facilitated care vs usual care: OR=2.98, P=.04); increased satisfaction with care for emotional problems among depressed patients (LSE: usual care=3.20, technology-facilitated care=3.70; P=.05); reduced total cholesterol level (LSE: usual care=176.40, technology-facilitated care=160.46; P=.01); improved satisfaction with diabetes care (LSE: usual care=4.01, technology-facilitated care=4.20; P=.05); and increased odds of taking an glycated hemoglobin test (technology-facilitated care vs usual care: OR=3.40, P<.001).
|
29685872 |
2018 |
|
Mental Depression
|
0.030 |
Biomarker
|
disease |
BEFREE |
LSE was associated with depression and anxiety symptoms.
|
28285253 |
2017 |
|
Depressive disorder
|
0.030 |
Biomarker
|
disease |
BEFREE |
LSE was associated with depression and anxiety symptoms.
|
28285253 |
2017 |
|
Depressed mood
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
LSE was associated with depression and anxiety symptoms.
|
28285253 |
2017 |
|
Nodule
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
(LSBR-3) (KF906140) and non-rhizobial nodule endophytic diazotroph Leclercia adecarboxylata (LSE-1) (KX925974) with multifunctional plant growth promoting (PGP) traits in cereal based cropping system (Rice-Wheat).
|
31673798 |
2019 |
|
Nodule
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Synergism of Pseudomonas aeruginosa (LSE-2) nodule endophyte with Bradyrhizobium sp. (LSBR-3) for improving plant growth, nutrient acquisition and soil health in soybean.
|
30834977 |
2019 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.020 |
Biomarker
|
disease |
BEFREE |
Sialic acid acetylesterase (SIAE) plays a crucial role in regulating the threshold of autoantibody production of B-cells and the defective variants of SIAE are associated with an increased risk of various autoimmune diseases such as type 1 diabetes (T1DM).
|
24748456 |
2014 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Functionally defective germline variant of sialic acid acetylesterase (Met89Val) is not associated with type 1 diabetes mellitus and Graves' disease in a Polish population.
|
21615338 |
2011 |
|
Degenerative polyarthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Symptoms of depression confirmed with depression inventory≥ 10 occurred as follows: patients with rheumatoid arthritis - 75.83%, patients with osteoarthritis - 50%, control group - 23.53% (p<0.0001), with the prevalence of insomnia (AIS≥6) at: 71%, 32% and 33%, respectively (p<0.001).
|
30286609 |
2019 |