|
West Syndrome
|
0.400 |
Biomarker
|
disease |
CTD_human |
Hypertrophic cardiomyopathy during corticotropin therapy for infantile spasms. A clinical and echocardiographic study.
|
8381257 |
1993 |
|
West Syndrome
|
0.400 |
Biomarker
|
disease |
CTD_human |
[Cardiac hypertrophy associated with subaortic obstruction induced by adrenocorticotropic hormone treatment].
|
1965992 |
1990 |
|
West Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
We encountered a 2-month-old boy with infantile spasms that had been treated with ACTH and had developed complicating Fournier's gangrene.
|
28007393 |
2017 |
|
West Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
Her infantile spasms and hypsarrhythmia disappeared promptly by adrenocorticotropic hormone therapy (CORTROSYN®Z, 0.0125mg/kg/day daily for 2weeks intramuscularly), though the administration of pyridoxal phosphate and valproic acid had poor efficacy.
|
28551038 |
2017 |
|
West Syndrome
|
0.400 |
Biomarker
|
disease |
CTD_human |
The seizures occurred following the suppression of infantile spasms with adrenocorticotropic hormone therapy and disappeared following the cessation of clonazepam administration.
|
1656808 |
1991 |
|
West Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
Since ACTH, the first line treatment for IS, has inconsistent efficacy and potential harsh side effects, PMX53, a potent complement C5ar1 antagonist, was suggested as a therapeutic alternative given its effects in other epilepsy models.
|
29636502 |
2018 |
|
West Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, it may be a candidate gene to be tested for responsiveness to ACTH in infantile spasms.
|
20722663 |
2010 |
|
West Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
Adrenocorticotropic hormone (ACTH) was a treatment of choice, and even in relapse of WS after ACTH therapy, the patients well responded to antiepileptic drugs.
|
11701255 |
2001 |
|
West Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
Very-High-Dose Prednisolone Before ACTH for Treatment of Infantile Spasms: Evaluation of a Standardized Protocol.
|
31331669 |
2019 |
|
West Syndrome
|
0.400 |
Biomarker
|
disease |
CTD_human |
[Secondary myocardial hypertrophy in newborn infants and infants without congenital heart defect].
|
2853496 |
1988 |
|
West Syndrome
|
0.400 |
Biomarker
|
disease |
CTD_human |
ACTH-induced seizures in an infant with West syndrome.
|
2554740 |
1989 |
|
West Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
Effectiveness of corticosteroids versus adrenocorticotropic hormone for infantile spasms: a systematic review and meta-analysis.
|
31657133 |
2019 |
|
West Syndrome
|
0.400 |
Biomarker
|
disease |
CTD_human |
Hormonal background of the hypertension and fluid derangements associated with adrenocorticotrophic hormone treatment of infants.
|
2551692 |
1989 |
|
West Syndrome
|
0.400 |
Biomarker
|
disease |
CTD_human |
A one-year-old boy presented with hypercalciuria and nephrolithiasis following a course of ACTH therapy for infantile spasms.
|
1324751 |
1992 |
|
West Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
Adrenocorticotropin hormone (ACTH) has been the standard treatment to infantile spasms (IS).
|
20042918 |
2010 |
|
West Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
The patient's spasms and hypsarrhythmia disappeared after a course of adrenocorticotropic hormone therapy, but focal seizures reappeared at the age of 3 years and 3 months.
|
19264735 |
2009 |
|
West Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
Adrenocorticotropic hormone (ACTH), vigabatrin (VGB) and corticosteroids are the first-line treatments for WS.
|
29086890 |
2018 |
|
West Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
At age 6 months, the infant demonstrated infantile spasms and craniosynostosis and was operated on for craniosynostosis and treated with adrenocorticotropic hormone (ACTH) for the infantile spasms.
|
14636357 |
2003 |
|
West Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
In addition, we also found that a 4-SNP haplotype (CAGC) which contains the aforementioned 2 SNPs, was associated with increased responsiveness to ACTH therapy in IS (p = 0.018, OR = 4.8) under recessive model.
|
25268096 |
2014 |
|
West Syndrome
|
0.400 |
Biomarker
|
disease |
CTD_human |
ACTH therapy in infantile spasms: side effects.
|
6254450 |
1980 |
|
West Syndrome
|
0.400 |
Biomarker
|
disease |
CTD_human |
A fatal incident during combined anticonvulsive therapy with ACTH and Dexamethason prompted us to reevaluate our treatment results in 19 children suffering from infantile spasms.
|
2983143 |
1985 |
|
West Syndrome
|
0.400 |
Biomarker
|
disease |
CTD_human |
Vigabatrin and ACTH showed no significant difference in the initial treatment of infantile spasms.
|
20078871 |
2010 |
|
West Syndrome
|
0.400 |
Therapeutic
|
disease |
CTD_human |
Cardiac vagal activation by adrenocorticotropic hormone treatment in infants with West syndrome.
|
17287597 |
2007 |
|
West Syndrome
|
0.400 |
Therapeutic
|
disease |
CTD_human |
Images in cardiology. Enlargement of cardiac rhabdomyoma and myocardial ischaemia during corticotropin treatment for infantile spasm.
|
10908253 |
2000 |
|
West Syndrome
|
0.400 |
Therapeutic
|
disease |
CTD_human |
Given the very poor prognosis of infantile spasms especially in such conditions as cerebral palsy, the combination of ACTH and vigabatrin appears to be an interesting therapy advance with very few side effects.
|
8980841 |
1997 |