|
Obesity
|
0.900 |
AlteredExpression
|
disease |
BEFREE |
In particular, both obesity and aging are associated with rewiring of a principal brain pathway modulating energy homeostasis, promoting reduced activity of satiety pro-opiomelanocortin (POMC) neurons within the arcuate nucleus of the hypothalamus (ARC).
|
25051442 |
2014 |
|
Obesity
|
0.900 |
Biomarker
|
disease |
BEFREE |
These findings further support the hypothesis that POMC-derived peptides might have a role in the control of peripheral glucose metabolism and suggest that disruption of central POMC secretion might represent an additional link between type 2 diabetes and obesity.
|
22643178 |
2012 |
|
Obesity
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Exon 3 hypermethylation in the POMC locus represents the first identified DNA methylation variant that is associated with the individual risk for obesity.
|
22438814 |
2012 |
|
Obesity
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Risk of substance dependence (SD) and obesity has been linked to the function of melanocortin peptides encoded by the proopiomelanocortin gene (POMC).
|
23028917 |
2012 |
|
Obesity
|
0.900 |
Biomarker
|
disease |
BEFREE |
Mutations that impair POMC sorting and processing are associated with obesity in humans and in animals.
|
21208604 |
2011 |
|
Obesity
|
0.900 |
Biomarker
|
disease |
BEFREE |
Earlier pharmacological and POMC gene transfer studies demonstrate that melanocortin activation in either site alone improves insulin sensitivity and reduces obesity.
|
21366729 |
2011 |
|
Obesity
|
0.900 |
Biomarker
|
disease |
BEFREE |
Alpha melanocyte stimulating hormone (αMSH), a key regulator of these neuronal pathways, is derived from pro-opiomelanocortin (POMC) which is therefore a prime target for the programming of obesity.
|
21211530 |
2011 |
|
Obesity
|
0.900 |
Biomarker
|
disease |
BEFREE |
In the present study, we therefore focused on dietary composition as a specific trait related to obesity and we determined whether genetic variations in leptin (LEP), LEP receptor (LEPR), adiponectin (ADIPOQ), IL-6 and pro-opiomelanocortin (POMC) underlie specific native food preferences and obesity-related anthropometric parameters.
|
19747414 |
2010 |
|
Obesity
|
0.900 |
PosttranslationalModification
|
disease |
BEFREE |
Hypothalamic proopiomelanocortin promoter methylation becomes altered by early overfeeding: an epigenetic model of obesity and the metabolic syndrome.
|
19723777 |
2009 |
|
Obesity
|
0.900 |
Biomarker
|
disease |
CTD_human |
Cushing's disease in dogs and humans.
|
19153526 |
2009 |
|
Obesity
|
0.900 |
Biomarker
|
disease |
BEFREE |
A new study in this issue of the JCI reveals the important role of neuropeptide degradation in regulating obesity (see the related article beginning on page 2291).Wallingford et al. provide evidence that, in mice, the enzyme prolylcarboxypeptidase (PRCP) degrades alpha-melanocyte-stimulating hormone (alpha-MSH) to an inactive form that is unable to inhibit food intake.
|
19620779 |
2009 |
|
Obesity
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
In this study, we did not find association between the frequently studied ENPP1 K121Q variant, nor SNPs in the MCR or POMC genes and obesity or type 2 diabetes.
|
18551113 |
2008 |
|
Obesity
|
0.900 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to investigate the possible associations of defined variability in leptin, leptin receptor, adiponectin, proopiomelanocortin and ghrelin genes with food preferences in the obese and non-obese Czech population and evaluate their potential as the obesity susceptibility genes.
|
18510797 |
2008 |
|
Obesity
|
0.900 |
Biomarker
|
disease |
BEFREE |
These mutations in patients with early-onset obesity represent a novel molecular mechanism of human POMC deficiency whereby naturally occurring mutations in its N-terminal sequence impair the ability of POMC to enter the trafficking pathway in which serial propeptide processing normally occurs.
|
18697863 |
2008 |
|
Obesity
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
The decreased response to alpha-MSH due to the intracellular retention of MC4R may cause early-onset obesity in the F261S pedigree of Chinese.
|
18837289 |
2008 |
|
Obesity
|
0.900 |
Biomarker
|
disease |
BEFREE |
Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity.
|
17728716 |
2007 |
|
Obesity
|
0.900 |
Biomarker
|
disease |
BEFREE |
Glucocorticoids exacerbate obesity and insulin resistance in neuron-specific proopiomelanocortin-deficient mice.
|
16440060 |
2006 |
|
Obesity
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
The availability of a large extended pedigree provided the opportunity to address whether loss of one copy of the POMC gene was sufficient to alter obesity risk.
|
16936203 |
2006 |
|
Obesity
|
0.900 |
AlteredExpression
|
disease |
BEFREE |
The obesity is associated with impaired autocatalytic activation of mature PC1 and reduced hypothalamic alpha-MSH.
|
16644867 |
2006 |
|
Obesity
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
These results show that a) the R236G substitution of POMC gene, although not a major cause of obesity among Italian obese children and adolescents, is associated with early onset obesity, and that b) inherited alterations of the melanocortin signaling pathway, independently of the degree of obesity, do not preclude the possibility to lose weight in mutated individuals following a hypocaloric diet.
|
16682835 |
2006 |
|
Obesity
|
0.900 |
Biomarker
|
disease |
CTD_human |
This reduction in POMC message is consistent with the onset of obesity in the animals.
|
16289378 |
2006 |
|
Obesity
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
We screened the POMC gene in 538 patients with severe, early-onset obesity and identified five unrelated probands who were heterozygous for a rare missense variant in the region encoding beta-MSH, Tyr221Cys.
|
16459314 |
2006 |
|
Obesity
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Our study advances the understanding of the molecular nature of hypothalamic POMC neurons and will be useful to determine whether polymorphisms in POMC regulatory regions play a role in the predisposition to obesity.
|
15798195 |
2005 |
|
Obesity
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Gene polymorphisms were identified in similar percentages of severely obese and nonobese individuals, i.e., respectively, 52.5% and 51% (POMC) and 1% and 2% (MC4R).
|
15951321 |
2005 |
|
Obesity
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Collectively, the POMC polymorphisms showed consistent evidence for association with obesity traits in Hispanic Americans across several analytical approaches using SNP and haplotype analysis.
|
16222047 |
2005 |