POMC, proopiomelanocortin, 5443

N. diseases: 873; N. variants: 39
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.090 Biomarker group BEFREE A systematic review and meta-analysis was conducted to determine the effects of prebiotics or synbiotics on blood biomarkers of obesity, depression, and anxiety (including: ACTH [adrenocorticotropic hormone], cortisol, leptin, ghrelin, TSH [thyroid-stimulating hormone], PTH [parathyroid hormone], vitamin D, BDNF [brain-derived neurotrophic factor], and PCR [polymerase chain reaction]) in individuals with overweight or obesity. 31504857 2020
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.090 Biomarker group BEFREE To evaluate HPA axis function, adrenocorticotropic hormone and corticosterone were measured in the serum of mice after the anxiety tests. 30882424 2019
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.090 AlteredExpression group BEFREE The effect of muscimol inactivation on the nociceptive response (hyperalgesia and allodynia), anxiety (elevated plus-maze), depressive-like behavior (forced swim test), motor activity (open field), and plasma stress hormone levels (corticosterone and adrenocorticotropic hormone) were evaluated in sham-operated and neuropathic animals. 30206257 2018
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.090 AlteredExpression group BEFREE Hamilton depression and anxiety scales (HAM-D and HAM-A) and estimation of serum beta-endorphin level pre and post-sessions were used as secondary outcome. 28684258 2018
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.090 Biomarker group BEFREE Gpx4 was deleted from either AgRP or POMC neurons in the hypothalamus, essential for metabolic homeostasis, or from dopaminergic neurons in the ventral midbrain, governing behaviors such as anxiety or voluntary movement. 28627418 2017
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.090 Biomarker group BEFREE In conclusion, we found that HRT increases the inhibitory influence of β-endorphin in the LC, which could, in turn, contribute to reduce anxiety and increase stress resilience. 28284896 2017
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.090 Biomarker group BEFREE Plasma ACTH concentration was significantly increased by both administration routes of CRF; however, hyperlocomotion and anxiety behavior were induced only by the i.c.v. administration. 28689880 2017
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.090 Biomarker group BEFREE Moreover, behavioral and functional studies demonstrated that POMC-Notch1<sup>-/-</sup> mutant mice showed anxiety and depressive-like behavior with impaired synaptic transmission properties in the dentate gyrus. 28611114 2017
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders
0.090 GeneticVariation group BEFREE The vasopressin receptor type 1b (AVPR1B) is mainly expressed by pituitary corticotropes and it mediates the stimulatory effects of AVP on ACTH release; common AVPR1B haplotypes have been involved in mood and anxiety disorders in humans, while rodents lacking a functional receptor gene display behavioral defects and altered stress responses. 19486526 2009