|
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
PON1*2/*2 showed a frequency of 6.6% versus 7.3% (P = 0.68 compared to wild-type), and PON1*3/3 occurred in 11.8% in CAD cases versus 10.3% among control individuals (P = 0.40).
|
10634138 |
1999 |
|
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
PON1 gene polymorphisms have been found to be associated with the variations in serum PON1 levels and activities, and with the risk for coronary artery disease (CAD).
|
15087255 |
2004 |
|
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Paraoxonase 1 (PON1) was implicated in susceptibility to coronary artery disease and stroke in previous studies.
|
16239632 |
2005 |
|
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Paraoxonase-1 (PON1) activity, but not PON1(Q192R) phenotype, is a predictor of coronary artery disease in a middle-aged Serbian population.
|
17032132 |
2006 |
|
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Paraoxonase 1 gene polymorphisms in angiographically assessed coronary artery disease: evidence for gender interaction among Brazilians.
|
17617030 |
2007 |
|
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Paraoxonase 1 gene polymorphisms in angiographically assessed coronary artery disease: evidence for gender interaction among Brazilians.
|
17617030 |
2007 |
|
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
PON1 status is influenced by oxidative stress and inflammation in coronary heart disease patients.
|
18634772 |
2008 |
|
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
PON-1 gene variants influence the 10-year risk of fatal complications from CAD in male patients, despite no effect on all-cause mortality.
|
19778663 |
2009 |
|
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Paraoxonase 1 (PON1) polymorphisms have been implicated as risk factors for coronary artery disease, but the results of genetic association studies on the related phenotype of ischemic stroke are inconclusive.
|
20856122 |
2010 |
|
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
PON1 and APOA5 polymorphisms may serve as biomarkers in the South Indian population to identify T2DM patients who are at risk of developing CAD.
|
21438666 |
2011 |
|
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
PON1 and PON2 have attracted considerable attention as candidate genes for coronary heart disease because their enzymes function as key factors in lipoprotein catabolism pathways.
|
23053877 |
2013 |
|
Coronary Artery Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Paraoxonase-1 (PON-1), a HDL-associated enzyme, showed a reduced activity in HDL isolated from CAD and ACS patients as compared to the controls (P<0.001).
|
23382833 |
2013 |
|
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
PON1 Q192R (rs662) had a significant effect on the risk of CAD (P=0.001).
|
24918121 |
2014 |
|
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Paraoxonase 1 (PON1) is located on HDL.Meta-analysis of clinical epidemiological investigations reveals a substantial association of low serum PON1 activity with coronary heart disease incidence independent of other risk factors including HDL cholesterol and apolipoprotein AI (apoAI).
|
26103614 |
2015 |
|
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
PON1 may also confer protection against coronary artery disease by destroying pro-inflammatory oxidized lipids present in oxidized low-density lipoproteins (LDLs).
|
9685159 |
1998 |
|
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A common polymorphism at codon 192(Q/R) of the PON 1 gene has been shown to be associated with an adverse lipoprotein profile and increased coronary artery disease (CAD) risk.
|
15488880 |
2004 |
|
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A common polymorphism of the PON1 gene modulates paraoxonase activity and has been related in some studies to coronary heart disease.
|
10831161 |
2000 |
|
Coronary Artery Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A common polymorphism of the PON1 gene, the PON1-192 genetic polymorphism, modulates PON1 activity and has been related in some studies to coronary heart disease.
|
11395042 |
2001 |
|
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A genome-wide association study identified distinct single nucleotide polymorphisms within the PON-1 gene that were highly significantly associated with serum paraoxonase (1.18×10(-303)) or arylesterase (4.99×10(-116)) activity but these variants were not associated with either 3-year MACE risk in an angiographic cohort (n=2136) or history of either coronary artery disease or myocardial infarction in the Coronary Artery Disease Genome-Wide Replication and Meta-Analysis consortium (n≈80 000 subjects).
|
22982463 |
2012 |
|
Coronary Artery Disease
|
0.400 |
Therapeutic
|
disease |
CTD_human |
A variant of human paraoxonase/arylesterase (HUMPONA) gene is a risk factor for coronary artery disease.
|
8675673 |
1995 |
|
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
CTD_human |
A variant of human paraoxonase/arylesterase (HUMPONA) gene is a risk factor for coronary artery disease.
|
8675673 |
1995 |
|
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
After controlling for other coronary risk factors, no association was found between PON1 alleles and the presence of CAD.
|
9763534 |
1998 |
|
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
After logistic regression analysis, current smoking, family history, fibrinogen, diabetes, and the ACE DD or ACE 8 GG + MTHFR 1298AA and ACE DD or ACE 8 GG + PON1 192RR associations remained in the, model and proved to be independent predictors of CAD.
|
19634497 |
2009 |
|
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Age and hypertension related changes in genotypes of MTHFR 677C>T, 1298A>C and PON1 -108C>T SNPs in men with coronary artery disease (CAD).
|
16077191 |
2005 |
|
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Age and hypertension related changes in genotypes of MTHFR 677C>T, 1298A>C and PON1 -108C>T SNPs in men with coronary artery disease (CAD).
|
16077191 |
2005 |