PON1, paraoxonase 1, 5444

N. diseases: 496; N. variants: 29
Disease: Rheumatoid Arthritis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.400 GeneticVariation disease BEFREE Functional implications of single nucleotide polymorphisms rs662 and rs854860 on the antioxidative activity of paraoxonase1 (PON1) in patients with rheumatoid arthritis. 30588556 2019
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.400 GeneticVariation disease BEFREE Synergistic effects of PON1 M55 and Q192 alleles resulted in 2.14 times (p = 0.021) increased disease activity among RA patients with moderate or high activity of the disease. 30506510 2019
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.400 AlteredExpression disease BEFREE PON1 activity was significantly lower in the RA group than in the control group (SMD = - 3.176, 95% CI = - 5.070 to - 1.283, p < 0.001). 30868319 2019
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.400 AlteredExpression disease BEFREE Specifically, decreases in RA disease activity over time were associated with increases in PON-1 activity and levels of HDL-associated Apo A-I, and decreases in the HDL inflammatory index and levels of MPO and HDL-associated Hp. 27483410 2017
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.400 GeneticVariation disease BEFREE PON-1 activity was decreased in RA patients compared to healthy controls (P = 0.005), and an effect of the rs662 genotype was noted in both groups, with Q/Q homozygotes exhibiting the lowest PON-1 activity. 26815637 2016
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.400 GeneticVariation disease BEFREE Thus, the objective of this study was to determine the relation of BuChE phenotypes and PON-1 Q192R polymorphism with inflammatory markers such as anti-cytroline circulated peptide (CCP)-antibodies, CRP, neopterin, DAS28-CRP in RA patients. 25179377 2015
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.400 GeneticVariation disease BEFREE Also, we studied RA markers in different genotypes of PON-1 of RA patients. 25406539 2014
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.400 AlteredExpression disease BEFREE Additional multivariate logistic regression analysis controlling for the above factors also revealed a significant association of plasma paraoxonase 1 activity with carotid plaque in RA patients. 23917967 2013
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.400 GeneticVariation disease BEFREE PON1 Q192R polymorphism was not found to be correlated with increased risk for rheumatoid arthritis in this Iranian population. 20198589 2010
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.400 GeneticVariation disease BEFREE In conclusion, the PON1 55MM genotype is a risk factor for rheumatoid arthritis. 20812194 2010
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.400 Biomarker disease CTD_human Assessment of paraoxonase 1 activity and malondialdehyde levels in patients with rheumatoid arthritis. 16055108 2005
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.400 Biomarker disease BEFREE There was a different distribution in PON1 Q/R genotypes between RA patients and healthy subjects, and RA patients exhibited less (44%) positive PON1-Q than did the healthy subjects (66%). 12697270 2003
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.400 AlteredExpression disease LHGDN Serum paraoxonase activity decreases in rheumatoid arthritis. 12697270 2003