PON1, paraoxonase 1, 5444

N. diseases: 496; N. variants: 29
Disease: Coronary Artery Vasospasm ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0010073
Disease: Coronary Artery Vasospasm
Coronary Artery Vasospasm 		0.320 GeneticVariation disease BEFREE First survey of the three gene polymorphisms (PON1 Q192R, eNOS E298D and eNOS C-786T) potentially associated with coronary artery spasm in African populations and comparison with worldwide data. 21287574 2011
CUI: C0010073
Disease: Coronary Artery Vasospasm
Coronary Artery Vasospasm 		0.320 GeneticVariation disease BEFREE The incidence of the PON1-192R allele was significantly higher in the coronary spasm group than in the control group (65% vs 53%; P=0.0005). 11810302 2002
CUI: C0010073
Disease: Coronary Artery Vasospasm
Coronary Artery Vasospasm 		0.320 Biomarker disease CTD_human Multiple logistic regression analysis with forward stepwise selection involving the PON1-192R allele and the environmental risk factors revealed that the most predictive independent risk factor for coronary spasm was the PON1-192R allele (significance=0.0016, OR=2.52), followed by cigarette smoking (significance=0.0007, OR=2.01). 11810302 2002