|
Hypertensive disease
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Among 10 studies that included 407 patients with surgically proven endometriosis and 557 controls, RR of developing hypercholesterolemia and hypertension were 1.25 and 1.14, respectively, while higher serum lipoprotein a and lower paraoxonase 1 levels were found in women with endometriosis that was negatively correlated with stage of disease (r = -0.74, P < 0.0001).
|
31735549 |
2019 |
|
Hypertensive disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The adiponectin TG genotype may be associated with reduced HDL-C and the human paraoxonase 1 AA genotype with hypertension in males.
|
30381540 |
2018 |
|
Hypertensive disease
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In this Caucasian cohort of men and women, HDL-C, but not its anti-oxidant constituent - PON-1, is inversely, continuously and independently associated with future risk of hypertension.
|
28667918 |
2017 |
|
Hypertensive disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In this study, association of PON-55 polymorphism with serum arylesterase (ARE) activities, malondialdehyde (MDA), neopterin, lipids and lipoproteins levels in SLE patients and the development of hypertension was investigated.
|
23893804 |
2013 |
|
Hypertensive disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The PON1 192R and 55M alleles absence was significantly associated with hypertension (OR: 2.59; 95% CI: 1.10-6.09) and hepatitis (OR: 21.43; 95% CI: 2.53-181.50), respectively, as indicated from backward logistic regression.
|
21718208 |
2011 |
|
Hypertensive disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Multiple linear regression analysis showed that LL genotype for PON1 (p < 0.03), high body mass index (BMI) values (p < 0.001) and low HDL-cholesterol levels (p < 0.05) are associated with high C-reactive protein levels independently from presence of stress-induced ischemia, age, sex, diabetes, hypertension, statin therapy, smoking and total cholesterol levels.
|
21231776 |
2011 |
|
Hypertensive disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The PON1 Q/R polymorphism was found to have significant association with hypertension (p=0.046) and chronic constipation (p=0.028) whereas, the L/M polymorphism, with diabetes (p=0.036), arteritis (trend p=0.022) and hemorrhoids (trend p=0.027).
|
19022366 |
2009 |
|
Hypertensive disease
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In biopsy specimens, immunohistochemical analysis found increased PON1 expression on the endothelial surface of sclerotic renal arterioles and glomerular capillaries in patients with hypertension or diabetes.
|
19357718 |
2009 |
|
Hypertensive disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The combined PON1 55/192 and MMP-3 5A/6A genetic variants are associated with CAD; PON1 seems to be connected with the number of diseased vessels, and hypertension and hyperlipidemia are related with PON1 192 and MMP-3 in CAD patients.
|
18830194 |
2008 |
|
Hypertensive disease
|
0.100 |
GeneticVariation
|
group |
LHGDN |
The combined PON1 55/192 and MMP-3 5A/6A genetic variants are associated with CAD; PON1 seems to be connected with the number of diseased vessels, and hypertension and hyperlipidemia are related with PON1 192 and MMP-3 in CAD patients.
|
18830194 |
2008 |
|
Hypertensive disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In the present study we have investigated the role of PON1 polymorphism on endothelial function in subjects with T2DM with or without hypertension.
|
18497471 |
2008 |
|
Hypertensive disease
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Risk factors associated with atherosclerosis, such as hypertension, dyslipidemia and smoking, also promote the progression of chronic glomerulonephritides which may therefore be associated with perturbations in PON1 activity.
|
17173245 |
2007 |
|
Hypertensive disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Oxidative stress and the PON1 (activity and Q192R polymorphism) were analysed in adolescent patients with essential (n = 49) or obesity-induced hypertension (n = 79), uraemic patients (n = 20), and also in obese normotensive patients (n = 60) and age-matched controls (n = 57).
|
16912512 |
2006 |
|
Hypertensive disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
A glutamine (Gln)/arginine (Arg) polymorphism at amino acid residue 192 in PON1 was significantly associated with stroke (P=0.003 in multivariate analysis, including age, sex, LDL, hypertension, diabetes, smoking, and pravastatin treatment as covariates).
|
16239632 |
2005 |
|
Hypertensive disease
|
0.100 |
AlteredExpression
|
group |
LHGDN |
Serum PON1 activity, oxLDL and malondialdehyde (MDA) concentrations and their relationship with serum lipid parameters and systolic and diastolic blood pressures (SBP and DBP) were determined in subjects with white coat hypertension (WCH), sustained hypertension (HT) and normotension (NT).
|
14985779 |
2004 |