|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Sex also strongly influenced the interplay between PON1 and both fat measures, with only the arylesterase showing a significant and independent inverse correlation with the former parameter (<i>r</i> = -0.248, <i>p</i><0.001) and the risk of overall obesity (odds ratio: 0.559, 95% confidence interval: 0.340-0.919) in women, but not in men; conversely, neither of the two activities remained associated with waist circumference in men or women after full adjustment.
|
31138960 |
2019 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Before RYGB, morbidly obese subjects had a lower PON1 concentration (P < 0.05) and higher PON lactonase activity (P < 0.001) than non-obese subjects, with no differences in PON arylesterase and PON paraoxonase activities.
|
30681756 |
2019 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Low levels of PON1 activity have been observed in association with obesity, a major risk factor for cardiovascular disease (CVD).
|
31390816 |
2019 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The aim of this study was to evaluate the levels of paraoxonase 1 (PON1), lectin-like oxidized LDL receptor-1 (LOX-1), antioxidant enzymes (superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx)), and lipid peroxidation processes in the course of obesity.
|
31737129 |
2019 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The aim of this study was to investigate whether obesity is associated with PON1 activity and whether this association is influenced by oxidative stress, inflammation and HDL cholesterol (HDL-C) concentration.
|
29168398 |
2018 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Relation of Paraoxonase 1 Activity with Biochemical Variables, Brachial Artery Intima-Media Thickness in Patients with Diabetes with or without Obesity.
|
29439274 |
2018 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The SNP rs662 in the paraoxonase 1 gene (PON1 Q192R) has been associated with obesity, dyslipidemia and cardiovascular risk.
|
25500007 |
2015 |
|
Obesity
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
TNF-α and PON promoter methylation levels could be involved in the susceptibility to stroke and obesity outcome, respectively.
|
24500802 |
2014 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
There were no significant associations between PON1 Q192R genotypes and smoking by genotype interactions and obesity or overweight, while body mass index significantly increased MetS risk.
|
25037113 |
2014 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Among the sixteen genotyped PON1 SNP, only the intronic SNP rs854566 exhibited a significant association with obesity (OR 0·61, 95 % CI 0·41, 0·91; P= 0·016).
|
23789921 |
2013 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Since PON1 polymorphisms and obesity both vary between ethnic groups, we estimated proportional genetic ancestry using 106 ancestral informative markers (AIMs).
|
23658746 |
2013 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aims of this study were i) to assess PON1 L55M and Q192R polymorphisms as a risk factor for obesity in women; ii) to compare PON1 activity according to the expression of each allele in L55M and Q192R polymorphisms; iii) to compare PON1 activity between obese and normal-weight women.
|
21078685 |
2011 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We investigated the association between PON1 Q192R polymorphism and the risk of myocardial infarction (MI) and in particular, whether the association can be modified by diabetes mellitus (DM) and obesity.
|
15654230 |
2005 |