PON1, paraoxonase 1, 5444

N. diseases: 496; N. variants: 29
Disease: Endothelial dysfunction ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction 		0.030 Biomarker phenotype BEFREE The aim of this study is to investigate whether and how PON1 glycation contributes to endothelial dysfunction in diabetes. 28374834 2017
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction 		0.030 Biomarker phenotype BEFREE PON1 is capable of hydrolyzing homocysteine thiolactone, a metabolite of homocysteine that can impair protein function leading to endothelial dysfunction and vascular damage. 22673025 2012
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction 		0.030 GeneticVariation phenotype BEFREE The 192Q>R allelic variant of the paraoxonase-1 gene is associated with coronary endothelial dysfunction. 18241625 2008