|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In summary, this meta-analysis proved that PON1 rs854560 polymorphism could be used to identify individual with elevated susceptibility to IS, whereas rs662 polymorphism could be used to identify individual with elevated susceptibility to CAD.
|
31302193 |
2019 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Paraoxonase 1 and 2 gene variants and the ischemic stroke risk in Gran Canaria population: an association study and meta-analysis.
|
26978533 |
2017 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Joint Effects of PON1 Polymorphisms and Vegetable Intake on Ischemic Stroke: A Family-Based Case Control Study.
|
29215590 |
2017 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Stratified analyses demonstrated a stronger association of PON1 variants with ischemic stroke in African ancestry (AA) participants (P = 5.03 × 10(-3)).
|
24711634 |
2014 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The salt stimulation property of serum paraoxonase (PON1) could be a valuable factor in evaluating the enzyme status in ischemic stroke: the role of activity-determined PON1 192Q/R phenotypes.
|
24433930 |
2014 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our study is the first to show that the miR-SNP at PON1 could affect genetic expression and is associated with an elevated risk for ischemic stroke and subclinical atherosclerosis.
|
23497787 |
2013 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The presence of rs705381 (-162) in the promoter region of PON1 was significantly associated with total stroke (P(adjusted) = 0.0007, OR = 0.57 [95% CI = 0.41-0.79]) and ischemic stroke (P(adjusted) = 0.0017, OR = 0.54 [95% CI = 0.37-0.79]) when analyzed using a dominant model, but was not associated with hemorrhagic stroke.
|
23356507 |
2013 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
It was found that the R allele or RR genotype of paraoxonase 1 Q192R polymorphism had an increased risk for ischaemic stroke in the general population (192R allele: odds ratio: 1·21, 95% confidence interval: 1·08-1·35, P = 0·0009 and 192RR genotype: odds ratio: 1·25, 95% confidence interval: 1·06-1·49, P = 0·009 in general population, respectively), but there was no significant association between other genetic variants of paraoxonase gene and ischaemic stroke.
|
22631428 |
2013 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The purpose of the study was to analyze PON1 192 Q/R polymorphism and the enzyme activities in ischemic stroke.
|
23054002 |
2012 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
There was an interaction between folate intake and PON1 Q192 polymorphism with regard to the risk of ischemic stroke in white subjects.
|
21982484 |
2011 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this study, we examined the association of ischemic stroke with the three PON genes.
|
19930448 |
2010 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We performed a meta-analysis of published studies investigating the association between ischemic stroke and two nonsynonymous PON1 polymorphisms, rs662 (p.Q192R) and rs854560 (rs854560" genes_norm="5444">p.L55M) in humans.
|
20856122 |
2010 |
|
Ischemic stroke
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This study assessed the association of single nucleotide polymorphisms (SNPs) in the PON1 5'-regulatory region with ischemic stroke and serum PON1 activity.
|
19233151 |
2009 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this study, we aimed to determine the importance of -107T/C, 192Q/R and 55L/M polymorphisms of PON1 gene and three PON1 activities (diazoxonase, paraoxonase, arylesterase) as risk factors for ischemic stroke.
|
19902425 |
2009 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study did not provide association between PON gene polymorphisms and ischemic stroke.
|
17854416 |
2008 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study identified PON1 activity ratio, PON1 192RR genotype and PON1 status as important risk factors for ischemic stroke.
|
17920578 |
2008 |
|
Ischemic stroke
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
PON1 activity and genotype in patients with arterial ischemic stroke and in healthy individuals.
|
17587252 |
2007 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We studied the significance of the Q192R and M55L polymorphisms of the PON1 gene and the C311S polymorphism of the PON2 gene in different etiologies of ischemic stroke.
|
17406108 |
2007 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To determine the association of the PON1 promoter polymorphisms with arterial ischemic stroke (AIS) in the young.DESIGN.
|
15023811 |
2004 |