RETREG1, reticulophagy regulator 1, 54463

N. diseases: 89; N. variants: 6
Disease: West Nile viral infection ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1096184
Disease: West Nile viral infection
West Nile viral infection 		0.020 AlteredExpression disease BEFREE Selective cleavage of FAM134B by Dengue, Zika, and West Nile virus encoded protease NS2B3 leads to the increased production of infection units, whereas upregulation of FAM134B inhibits viral replication. 29226326 2018
CUI: C1096184
Disease: West Nile viral infection
West Nile viral infection 		0.020 Biomarker disease BEFREE Consistent with its role as an antiviral host factor, we found that several flaviviruses including DENV, ZIKV, and West Nile virus (WNV), utilize their NS3 virally-encoded proteases to directly cleave FAM134B at a single site within its reticulon homology domain (RHD). 28102736 2017