TOLLIP, toll interacting protein, 54472

N. diseases: 40; N. variants: 10
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1800706
Disease: Idiopathic Pulmonary Fibrosis
Idiopathic Pulmonary Fibrosis 		0.160 GeneticVariation disease BEFREE Furthermore, genetic variants of TOLLIP, MUC-5B, and other genes associated with a differential response to treatment and with the development and/or the prognosis of IPF are reported. 30526140 2019
CUI: C1800706
Disease: Idiopathic Pulmonary Fibrosis
Idiopathic Pulmonary Fibrosis 		0.160 GeneticVariation disease BEFREE Furthermore, genetic variants of TOLLIP, MUC5B, and other genes are associated with a differential response to treatment and with the development and/or the prognosis of IPF. 29408012 2018
CUI: C1800706
Disease: Idiopathic Pulmonary Fibrosis
Idiopathic Pulmonary Fibrosis 		0.160 GeneticVariation disease BEFREE We measured two common single-nucleotide polymorphisms associated with IPF (MUC5B rs35705950 and TOLLIP rs5743890) and telomere length in peripheral blood leucocytes, and assessed their associations with chronic hypersensitivity pneumonitis risk, survival, and clinical, radiographic, and pathological features. 28648751 2017
CUI: C1800706
Disease: Idiopathic Pulmonary Fibrosis
Idiopathic Pulmonary Fibrosis 		0.160 GeneticVariation disease BEFREE A recent pharmacogenetic analysis of patients enrolled in an IPF clinical trial identified a variant within TOLLIP to be associated with differential response to N-acetylcysteine therapy. 27253772 2016
CUI: C1800706
Disease: Idiopathic Pulmonary Fibrosis
Idiopathic Pulmonary Fibrosis 		0.160 GeneticVariation disease BEFREE Polymorphisms in the MUC5B promoter, TOLLIP, and nine additional genetic loci have been associated with idiopathic pulmonary fibrosis (IPF) within non-Hispanic white populations. 25275363 2015
CUI: C1800706
Disease: Idiopathic Pulmonary Fibrosis
Idiopathic Pulmonary Fibrosis 		0.160 GeneticVariation disease GWASCAT Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study. 24429156 2013
CUI: C1800706
Disease: Idiopathic Pulmonary Fibrosis
Idiopathic Pulmonary Fibrosis 		0.160 GeneticVariation disease GWASDB Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study. 24429156 2013
CUI: C1800706
Disease: Idiopathic Pulmonary Fibrosis
Idiopathic Pulmonary Fibrosis 		0.160 AlteredExpression disease BEFREE These associations and the reduced expression of TOLLIP in patients with IPF who carry TOLLIP SNPs emphasise the importance of this gene in the disease. 24429156 2013
CUI: C0206062
Disease: Lung Diseases, Interstitial
Lung Diseases, Interstitial 		0.100 GeneticVariation group GWASDB Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis. 23583980 2013
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.040 GeneticVariation disease BEFREE Evaluation of TLR2, TLR4, and TOLLIP polymorphisms for their role in tuberculosis susceptibility. 29924447 2018
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.040 Biomarker disease BEFREE To identify functional TOLLIP variants and evaluate the role of TOLLIP variation on innate and adaptive immune responses to mycobacteria and susceptibility to tuberculosis. 28463648 2017
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.040 GeneticVariation disease BEFREE Multiple SNPs in IL4 and TOLLIP were associated with TB (P < 0.05). 25521228 2015
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.040 Biomarker disease BEFREE These data demonstrate that TOLLIP has an anti-inflammatory effect on TLR signaling in humans and that TOLLIP deficiency is associated with an increased risk of tuberculosis. 22778396 2012
CUI: C0276447
Disease: Rhinovirus infection
Rhinovirus infection 		0.020 GeneticVariation disease BEFREE Both IL6 and TOLLIP polymorphisms but not TNFA or IL1B influenced Rhinovirus detection in the nostrils of voluntaries. 31350695 2019
CUI: C0004096
Disease: Asthma
Asthma 		0.020 AlteredExpression disease BEFREE Tollip genetic variation has been associated with airflow limitation in asthma subjects and Tollip expression. 29393212 2018
CUI: C1609538
Disease: Latent Tuberculosis
Latent Tuberculosis 		0.020 Biomarker disease BEFREE This study was designed to investigate potential associations between the polymorphisms in TLR2, TLR4, and TOLLIP and susceptibility to latent tuberculosis infection (LTBI) or subsequent PTB in a Chinese Han population. 29924447 2018
CUI: C0027765
Disease: nervous system disorder
nervous system disorder 		0.020 Biomarker group BEFREE Our data suggest that Tollip may play a crucial role in sustaining neuron health by facilitating the completion of autophagy, and that Tollip-deficiency may accelerate neuron death related to neurological disease such as Alzheimer's disease. 27720815 2017
CUI: C1609538
Disease: Latent Tuberculosis
Latent Tuberculosis 		0.020 GeneticVariation disease BEFREE We also examined the association of TOLLIP variation with BCG-induced T-cell responses and susceptibility to latent tuberculosis infection. 28463648 2017
CUI: C4082937
Disease: Necrotizing enterocolitis in fetus OR newborn
Necrotizing enterocolitis in fetus OR newborn 		0.020 AlteredExpression disease BEFREE This study demonstrated B. adolescentis prevents NEC in preterm neonatal rats and that the mechanism for this action might be associated with the alteration of TLR4, TOLLIP, and SIGIRR expression. 28056921 2017
CUI: C0004096
Disease: Asthma
Asthma 		0.020 GeneticVariation disease BEFREE DNA from blood of asthmatic and normal subjects was genotyped for Tollip SNP rs5743899 AA, AG and GG genotypes. 27513438 2016
CUI: C0023343
Disease: Leprosy
Leprosy 		0.020 Biomarker disease BEFREE Inhibition of TOLLIP may decrease an individual's susceptibility to leprosy and offer a novel therapeutic target for IL-1-dependent diseases. 26610735 2016
CUI: C0276447
Disease: Rhinovirus infection
Rhinovirus infection 		0.020 Biomarker disease BEFREE The major goal was to determine the role of genetic variation [e.g. single nucleotide polymorphisms (SNPs)] of Toll-interacting protein (Tollip) in airway epithelial responses to RV in a type 2 cytokine milieu. 27513438 2016
CUI: C2363741
Disease: HIV-1 infection
HIV-1 infection 		0.020 Biomarker disease BEFREE Our data indicate a key role of Tollip in suppressing HIV-1 infection and regulating viral latency, which provides a potential host target for combating HIV-1 infection and latency. 27181351 2016
CUI: C0027765
Disease: nervous system disorder
nervous system disorder 		0.020 Biomarker group BEFREE However, the role of Tollip in neurological disease remains unknown. 26011492 2015
CUI: C2363741
Disease: HIV-1 infection
HIV-1 infection 		0.020 Biomarker disease BEFREE Further elucidation of the mechanisms by which HIV-1 induces Tollip expression and identification of the role of Tollip in modulating HIV-1 latency will facilitate the understanding of host regulation in viral replication and benefit the exploration of novel strategies for combating HIV-1 infection. 25915421 2015