|
11 pairs of ribs
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Aarskog syndrome
|
0.200 |
Biomarker
|
disease |
MGD |
|
|
|
|
Abnormal finger flexion creases
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Abnormality of dental enamel
|
0.100 |
Biomarker
|
group |
HPO |
|
|
|
|
Abnormality of the pinna
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Abnormality of the skeletal system
|
0.010 |
Biomarker
|
disease |
BEFREE |
ATR-X is characterized by severe mental retardation, mild HbH disease, dysmorphic facies, and genital and skeletal abnormalities.
|
16376512 |
2006 |
|
Abnormally large globe
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Absent earlobe
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Acute lymphocytic leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
rRNA synthesis inhibitor, CX-5461, activates ATM/ATR pathway in acute lymphoblastic leukemia, arrests cells in G2 phase and induces apoptosis.
|
26061708 |
2015 |
|
Acute monocytic leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Targeting the kinase activities of ATR and ATM exhibits antitumoral activity in mouse models of MLL-rearranged AML.
|
27625305 |
2016 |
|
Adenocarcinoma Of Esophagus
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our aim was to develop an accurate and inexpensive method using biofluids (plasma, serum, saliva or urine) for detecting oesophageal stages through to OAC (squamous; inflammatory; Barrett's; low-grade dysplasia; high-grade dysplasia; OAC) using attenuated total reflection Fourier-transform infrared (ATR-FTIR) spectroscopy.
|
31696873 |
2019 |
|
Adenocarcinoma of lung (disorder)
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
In lung adenocarcinoma (LAC), we also determined the expression of phosphorylated ataxia telangiectasia mutated kinase and ataxia telangiectasia and Rad3-related protein.
|
31323387 |
2019 |
|
Adenocarcinoma of lung (disorder)
|
0.320 |
Biomarker
|
disease |
BEFREE |
<i>ATM</i> Deficiency Is Associated with Sensitivity to PARP1- and ATR Inhibitors in Lung Adenocarcinoma.
|
28363999 |
2017 |
|
Adenocarcinoma of lung (disorder)
|
0.320 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Adenoma
|
0.010 |
Biomarker
|
group |
BEFREE |
To determine the specificity of 11q21 locus rearrangements for MEC, fluorescence in situ hybridization analysis with specific MEC-I Dual Color Break Apart Probe was performed on a tissue microarray containing samples from almost 1200 salivary gland adenomas and carcinomas.
|
22847156 |
2012 |
|
Adenovirus Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
Here, we show that the cellular DNA replication protein and ATR substrate SMARCAL1 is recruited to viral replication centers early during adenovirus infection and is then targeted in an E1B-55K/E4orf6- and cullin RING ligase-dependent manner for proteasomal degradation.
|
30996091 |
2019 |
|
Adrenal Cushing's syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
ATR-101 pharmacokinetics and activity were assessed in 10 dogs with naturally-occurring Cushing's syndrome, including 7 dogs with pituitary-dependent disease and 3 dogs with adrenal-dependent disease.
|
29720169 |
2018 |
|
Adrenocortical carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
ATR-101 inhibits cholesterol efflux and cortisol secretion by ATP-binding cassette transporters, causing cytotoxic cholesterol accumulation in adrenocortical carcinoma cells.
|
28710789 |
2017 |
|
Adrenocortical carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
ATR-101, a selective inhibitor of ACAT1 (acyl coenzyme A:cholesterol acyltransferase 1), is a novel small molecule therapeutic currently in clinical development for the treatment of adrenocortical carcinoma, congenital adrenal hyperplasia, and Cushing's syndrome in humans.
|
29720169 |
2018 |
|
Adult Glioblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Contribution of ATM and ATR to the resistance of glioblastoma and malignant melanoma cells to the methylating anticancer drug temozolomide.
|
23960094 |
2013 |
|
Adult Glioblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Myc targeted CDK18 promotes ATR and homologous recombination to mediate PARP inhibitor resistance in glioblastoma.
|
31266951 |
2019 |
|
Adult Hepatocellular Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the study the modulating effect of inhibition of phosphatidylinositol 3-kinase-related kinases (PIKK): ATM (Ataxia Telangiectasia Mutated), ATR (Ataxia Telangiectasia and Rad3 Related) and DNA-PK (DNA-dependent protein kinase) on genotoxicity of dibenzo[def,p]chrysene (DBC) in HepG2 human hepatocellular cancer cells was investigated.
|
31838185 |
2020 |
|
Adult Hodgkin Lymphoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
These findings suggested the role of ATR gene alterations in HL lymphomagenesis.
|
18357388 |
2008 |
|
Adult Lymphoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
We have reported micro-SPECT/CT imaging of Mec-1 human lymphoma xenografts in SCID mice, using [(111)In]DOTA-anti-bcl-2-PNA-Tyr(3)-octreotate.
|
26239085 |
2015 |
|
Adult Lymphoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
ATR-FTIR spectral discrimination between normal and tumorous mouse models of lymphoma and melanoma from serum samples.
|
29209060 |
2017 |