|
Astigmatism
|
0.010 |
Biomarker
|
disease |
BEFREE |
Outcome comparisons between the two correction modalities were performed by grouping in different amounts (- 0.50 D, - 0.75 D) and axes (with the rule, WTR; against the rule, ATR; oblique, OBL) of astigmatism.
|
31641885 |
2020 |
|
Childhood Hepatocellular Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the study the modulating effect of inhibition of phosphatidylinositol 3-kinase-related kinases (PIKK): ATM (Ataxia Telangiectasia Mutated), ATR (Ataxia Telangiectasia and Rad3 Related) and DNA-PK (DNA-dependent protein kinase) on genotoxicity of dibenzo[def,p]chrysene (DBC) in HepG2 human hepatocellular cancer cells was investigated.
|
31838185 |
2020 |
|
Adult Hepatocellular Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the study the modulating effect of inhibition of phosphatidylinositol 3-kinase-related kinases (PIKK): ATM (Ataxia Telangiectasia Mutated), ATR (Ataxia Telangiectasia and Rad3 Related) and DNA-PK (DNA-dependent protein kinase) on genotoxicity of dibenzo[def,p]chrysene (DBC) in HepG2 human hepatocellular cancer cells was investigated.
|
31838185 |
2020 |
|
Malignant neoplasm of liver
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the study the modulating effect of inhibition of phosphatidylinositol 3-kinase-related kinases (PIKK): ATM (Ataxia Telangiectasia Mutated), ATR (Ataxia Telangiectasia and Rad3 Related) and DNA-PK (DNA-dependent protein kinase) on genotoxicity of dibenzo[def,p]chrysene (DBC) in HepG2 human hepatocellular cancer cells was investigated.
|
31838185 |
2020 |
|
Adenovirus Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
Here, we show that the cellular DNA replication protein and ATR substrate SMARCAL1 is recruited to viral replication centers early during adenovirus infection and is then targeted in an E1B-55K/E4orf6- and cullin RING ligase-dependent manner for proteasomal degradation.
|
30996091 |
2019 |
|
Chondrosarcoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We found that chondrosarcoma cells expressed very low basal levels of phosphorylated ATR, but cisplatin treatment induced the activation of ATR-Chk1 signaling in a dose- and time-dependent manner, suggesting the induction of DDR.
|
31839711 |
2019 |
|
Colorectal Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Inhibition of PML and APBs by an ATR inhibitor decreases proliferation of CSLCs and organoids, suggesting a potential therapeutic target to progressive colorectal tumors.
|
31207547 |
2019 |
|
Dehydration
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy establishes that this transition is driven by dehydration of the esterified galacturonic acid residues along the pectin backbone.
|
30660012 |
2019 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.010 |
Biomarker
|
disease |
BEFREE |
Inhibition of PML and APBs by an ATR inhibitor decreases proliferation of CSLCs and organoids, suggesting a potential therapeutic target to progressive colorectal tumors.
|
31207547 |
2019 |
|
Marek Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results suggest that MDV infection activates STAT3 to disable the ATR-Chk1 pathway, which is conducive to viral replication.
|
30787154 |
2019 |
|
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In an orthotopic breast cancer model, tumor-selective synthetic lethality of the combination of bioavailable ATR and Wee1 inhibitors led to tumor remission and inhibited metastasis with minimal side effects.
|
30645202 |
2019 |
|
Parkinson Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here we found that miR-7 was upregulated in brain tissue but downregulated in peripheral blood of rats with ATR-induced PD.
|
31185338 |
2019 |
|
Stress, Psychological
|
0.010 |
Biomarker
|
disease |
BEFREE |
Applicability of FTIR-ATR Method to Measure Carbonyls in Blood Plasma after Physical and Mental Stress.
|
31032337 |
2019 |
|
Onychomycosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our data suggest that ATR-FTIR spectroscopy may be a promising, fast and accurate method to determine onychomycosis, including identification of the causative organism, bypassing the need for lengthy fungal cultures.
|
30216405 |
2019 |
|
Adult Soft Tissue Sarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
<i>In vivo</i>, simultaneous inhibition of ATR and GLUT1 significantly reduced tumor volume gain in an autochthonous mouse model of <i>Kras<sup>G12D</sup></i> -driven soft tissue sarcoma.
|
31405847 |
2019 |
|
Childhood Soft Tissue Sarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
<i>In vivo</i>, simultaneous inhibition of ATR and GLUT1 significantly reduced tumor volume gain in an autochthonous mouse model of <i>Kras<sup>G12D</sup></i> -driven soft tissue sarcoma.
|
31405847 |
2019 |
|
Adenocarcinoma Of Esophagus
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our aim was to develop an accurate and inexpensive method using biofluids (plasma, serum, saliva or urine) for detecting oesophageal stages through to OAC (squamous; inflammatory; Barrett's; low-grade dysplasia; high-grade dysplasia; OAC) using attenuated total reflection Fourier-transform infrared (ATR-FTIR) spectroscopy.
|
31696873 |
2019 |
|
Laryngeal Squamous Cell Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
DIAPH1 Is Upregulated and Inhibits Cell Apoptosis through ATR/p53/Caspase-3 Signaling Pathway in Laryngeal Squamous Cell Carcinoma.
|
30733838 |
2019 |
|
Human papilloma virus infection
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we used our raft culture system to examine effects of inhibitors of ATR/Chk1 and ATM/Chk2 on HPV infection.
|
31683862 |
2019 |
|
Biliary Tract Cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
A total of nine human BTC cell lines were used for evaluating anti-tumor effect of AZD6738 (ATR inhibitor) alone or combination with cytotoxic chemotherapeutic agents through MTT assay, colony-forming assays, cell cycle analyses, and comet assays.
|
30514066 |
2019 |
|
Sarcoma
|
0.010 |
Biomarker
|
group |
BEFREE |
<i>In vivo</i>, simultaneous inhibition of ATR and GLUT1 significantly reduced tumor volume gain in an autochthonous mouse model of <i>Kras<sup>G12D</sup></i> -driven soft tissue sarcoma.
|
31405847 |
2019 |
|
Mammary Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The protein level of ATR was lowered by about 50% in breast tumors of WA-treated mouse mammary tumor virus-neu mice when compared with vehicle-treated controls but the difference was not significant due to small sample size.
|
31441116 |
2019 |
|
Non-Metastatic Childhood Soft Tissue Sarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
<i>In vivo</i>, simultaneous inhibition of ATR and GLUT1 significantly reduced tumor volume gain in an autochthonous mouse model of <i>Kras<sup>G12D</sup></i> -driven soft tissue sarcoma.
|
31405847 |
2019 |
|
Sarcoma of soft tissue
|
0.010 |
Biomarker
|
group |
BEFREE |
<i>In vivo</i>, simultaneous inhibition of ATR and GLUT1 significantly reduced tumor volume gain in an autochthonous mouse model of <i>Kras<sup>G12D</sup></i> -driven soft tissue sarcoma.
|
31405847 |
2019 |
|
Bacterial Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
Importantly, neither CI-1040 nor ATR-002 treatment led to increased bacterial titres during super-infection, indicating that the drug does not sensitize cells for bacterial infection.
|
29904167 |
2018 |