Disease: Psoriasis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0033860
Disease: Psoriasis
Psoriasis 		0.200 GeneticVariation disease GWASCAT Genome-wide association study of psoriasis in an Egyptian population. 30921485 2019
CUI: C0033860
Disease: Psoriasis
Psoriasis 		0.200 Biomarker disease BEFREE Intracellular signalling pathways and cytoskeletal functions converge on the psoriasis candidate gene CCHCR1 expressed at P-bodies and centrosomes. 29866042 2018
CUI: C0033860
Disease: Psoriasis
Psoriasis 		0.200 GeneticVariation disease BEFREE PSORS1C2 is a gene located between coiled-coil alpha-helical rod protein 1 (CCHCR1) and corneodesmosin (CDSN) within the psoriasis susceptibility locus 1 (PSORS1). 27943452 2017
CUI: C0033860
Disease: Psoriasis
Psoriasis 		0.200 GeneticVariation disease BEFREE When we compared type I psoriasis with type II psoriasis (N = 36), we found a significant association between age at onset and the genes PSORS6, TNF-α, FCGR2A, TNFR1, CD226, HLA-C, TNFAIP3, and CCHCR1. 26613086 2015
CUI: C0033860
Disease: Psoriasis
Psoriasis 		0.200 GeneticVariation disease BEFREE After applying a Bonferroni correction for the number of SNPs tested, the SNP mapping to CCHCR1 (rs130067) retained statistically significant evidence for association (P = 6 × 10(-4) ; odds ratio [OR] = 1.15, 95% CI: 1.06-1.24); this has also been associated with psoriasis. 22985493 2013
CUI: C0033860
Disease: Psoriasis
Psoriasis 		0.200 AlteredExpression disease BEFREE The isoform 1 with the non-risk allele induces the expression of keratin 17, a hallmark for psoriasis; the silencing of CCHCR1 reduces its expression in HEK293 cells. 23189171 2012
CUI: C0033860
Disease: Psoriasis
Psoriasis 		0.200 AlteredExpression disease BEFREE Different from psoriasis, Ki67 had a similar expression pattern as CCHCR1. 19551138 2009
CUI: C0033860
Disease: Psoriasis
Psoriasis 		0.200 AlteredExpression disease BEFREE CCHCR1 has an altered expression pattern in lesional psoriatic skin compared to normal healthy skin, suggesting its dysregulation in psoriasis. 17221218 2007
CUI: C0033860
Disease: Psoriasis
Psoriasis 		0.200 GeneticVariation disease LHGDN Presence of psoriatic arthritis was more pronounced in HCR- psoriasis (as well as in Cw6- psoriasis). 17340018 2007
CUI: C0033860
Disease: Psoriasis
Psoriasis 		0.200 GeneticVariation disease BEFREE Presence of psoriatic arthritis was more pronounced in HCR- psoriasis (as well as in Cw6- psoriasis). 17340018 2007
CUI: C0033860
Disease: Psoriasis
Psoriasis 		0.200 GeneticVariation disease BEFREE I review two examples of such challenges: the cloning of GPR154 (GPRA) and AAA1 on chromosome 7p14 at a susceptibility locus for atopy and asthma, and the study of HLA-Cw6, CCHCR1 (HCR) and CDSN on chromosome 6p21 at PSORS1, the major susceptibility locus for psoriasis. 16096103 2005
CUI: C0033860
Disease: Psoriasis
Psoriasis 		0.200 Biomarker disease BEFREE With two rounds of the method and five single nucleotide polymorphisms, molecular haplotypes of 29.3 kb spanning the HCR and CDSN genes, two genes associated with the susceptibility of psoriasis, of 11 members, belonging to a CEPH family, were revealed. 16134125 2005
CUI: C0033860
Disease: Psoriasis
Psoriasis 		0.200 GeneticVariation disease BEFREE Expression studies using Affymetrix arrays suggested that the HCR risk allele has specific functional consequences relevant to the pathogenesis of psoriasis. 15190014 2004
CUI: C0033860
Disease: Psoriasis
Psoriasis 		0.200 GeneticVariation disease BEFREE We aimed to determine whether the genetic polymorphisms of the HCR gene, SNPs n.7*A, and n.9*C were associated with an increased risk of psoriasis in Chinese patients. 15214895 2004
CUI: C0033860
Disease: Psoriasis
Psoriasis 		0.200 AlteredExpression disease BEFREE To understand better the function of HCR, we studied how HCR expression is altered in hyperproliferative skin diseases other than psoriasis and in cancers. 14675183 2003
CUI: C0033860
Disease: Psoriasis
Psoriasis 		0.200 GeneticVariation disease BEFREE These results provide strong evidence for the HCR*WWCC allele as a major genetic determinant for psoriasis, probably by a mechanism impacting on keratinocyte proliferation. 11875053 2002
CUI: C0033860
Disease: Psoriasis
Psoriasis 		0.200 Biomarker disease BEFREE The HCR gene on 6p21 is unlikely to be a psoriasis susceptibility gene. 11348465 2001
CUI: C0033860
Disease: Psoriasis
Psoriasis 		0.200 Biomarker disease BEFREE Our results suggest a potential role for HCR in the pathogenesis of psoriasis. 10888604 2000