|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We summarize the role of BRN2 in tumour cell dissemination and metastasis in melanoma, while also examining it as a potential metastatic regulator in other tumour models.
|
29781575 |
2019 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
A PAX3/BRN2 rheostat controls the dynamics of BRAF mediated MITF regulation in MITF<sup>high</sup> /AXL<sup>low</sup> melanoma.
|
30277012 |
2019 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
By promoting error-prone DNA damage repair via NHEJ and suppressing apoptosis of damaged cells, our results suggest that BRN2 contributes to the generation of melanomas with a high mutation burden.
|
30804224 |
2019 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
BRN2 transcription factor is associated with the development of malignant melanoma.
|
30417795 |
2019 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Using CRISPR-Cas9 to engineer a cellular model of melanoma initiation from primary human melanocytes, we discovered that a lineage-restricted transcription factor, BRN2, is downstream of CDKN2A and directly regulated by E2F1.
|
29990501 |
2018 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
NFIB Mediates BRN2 Driven Melanoma Cell Migration and Invasion Through Regulation of EZH2 and MITF.
|
28119061 |
2017 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This finding highlights the importance of BRN2 and MITF expression in development of melanoma metastasis.
|
28883623 |
2017 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Mechanistically, we found that NFATc2 controls melanoma dedifferentiation by inducing expression in neoplastic cells of membrane-bound tumor necrosis factor-α (mTNF-α) and that melanoma-expressed TNF-α regulates a c-myc-Brn2 axis.
|
26387540 |
2016 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Given the key role of Brn-2 in regulating melanoma biology, understanding the signaling pathways that drive Brn-2 expression is an important issue.
|
22988297 |
2012 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The study has identified CDH13 as a novel direct BRN2 transcriptional target gene and has advanced knowledge of mechanisms underlying loss of T-cadherin expression in melanoma.
|
23069940 |
2012 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We propose a model for the apparent non-overlapping expression levels of BRN2 and MITF in melanoma, mediated by miR-211 expression.
|
21435193 |
2011 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Loss of the BRN2-MITF axis in antisense-ablated cell lines decreased the melanoma sphere-forming capability, cell adhesion during 3D-spheroid formation and invasion through a collagen matrix.
|
21358674 |
2011 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
N Oct-3 is a master gene for central nervous system development but also for melanoma progression.
|
18996486 |
2009 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Nestin protein was detected in 11 of 13 and BRN2 protein in 7 of 13 melanoma cell lines independent of progression stage.
|
18923447 |
2009 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
N Oct-3 is a master gene for central nervous system development but also for melanoma progression.
|
18996486 |
2009 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The Brn-2 (N-Oct-3, POU3F2) transcription factor also regulates melanoma proliferation and is up-regulated by BRAF and beta-catenin, two key melanoma-associated signaling molecules.
|
18829533 |
2008 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
The results suggest that the high levels of Brn-2 expression observed in melanomas link BRAF signaling to increased proliferation.
|
15024080 |
2004 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The POU domain transcription factor Brn-2 has been implicated in control of proliferation and melanoma survival, and its expression is strongly upregulated in melanoma.
|
15024079 |
2004 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The results suggest that the high levels of Brn-2 expression observed in melanomas link BRAF signaling to increased proliferation.
|
15024080 |
2004 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Brn-2 has also been found to regulate the melanocytic phenotype with N-Oct-3 DNA binding activity elevated in malignant melanoma, however, its mode of action is yet to be defined.
|
11029584 |
2000 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Brn-2 C-terminal antibody Western blot analysis of melanoma cell line nuclear extracts prepared using a combination of sodium dodecyl sulphate and NP-40 detergent cell lysis procedures demonstrated the formation of N-Oct-5 DNA binding activity via N-terminal proteolytic clipping of Brn-2/N-Oct-3.
|
9508370 |
1998 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Brn-2 is normally expressed at high levels in melanoblasts and melanomas but only at low levels in normal melanocytes.
|
8873046 |
1996 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The POU domain transcription factor Brn-2: elevated expression in malignant melanoma and regulation of melanocyte-specific gene expression.
|
7478537 |
1995 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest roles for brn-2 in the determination of the melanocytic lineage and in the tumorigenic phenotype of melanoma.
|
7651733 |
1995 |